Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1534333..1534897 Replicon chromosome
Accession NZ_AP024240
Organism Mycobacterium paraintracellulare strain M001

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MINTM021_RS07560 Protein ID WP_201358822.1
Coordinates 1534526..1534897 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MINTM021_RS07555 Protein ID WP_026071432.1
Coordinates 1534333..1534539 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MINTM021_RS07535 1529948..1530946 + 999 WP_008254378.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
MINTM021_RS07540 1530992..1532137 - 1146 WP_193375537.1 hypothetical protein -
MINTM021_RS07545 1532279..1533352 + 1074 WP_009953440.1 redox-regulated ATPase YchF -
MINTM021_RS07550 1533432..1534094 - 663 WP_202377983.1 methyltransferase domain-containing protein -
MINTM021_RS07555 1534333..1534539 + 207 WP_026071432.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MINTM021_RS07560 1534526..1534897 + 372 WP_201358822.1 type II toxin-antitoxin system VapC family toxin Toxin
MINTM021_RS07565 1534955..1535506 + 552 WP_038535279.1 VOC family protein -
MINTM021_RS07570 1535585..1535983 + 399 WP_009953435.1 VOC family protein -
MINTM021_RS07575 1536130..1536465 + 336 WP_014379387.1 hypothetical protein -
MINTM021_RS07580 1536551..1536910 + 360 WP_179960061.1 hypothetical protein -
MINTM021_RS07585 1537092..1537667 + 576 WP_085977620.1 C40 family peptidase -
MINTM021_RS07590 1538030..1538353 + 324 WP_009953431.1 antibiotic biosynthesis monooxygenase -
MINTM021_RS07595 1538402..1539085 - 684 WP_014384004.1 hypothetical protein -
MINTM021_RS07600 1539232..1539441 + 210 WP_014381976.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-111)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13896.21 Da        Isoelectric Point: 6.8398

>T38185 WP_201358822.1 NZ_AP024240:1534526-1534897 [Mycobacterium paraintracellulare]
VILVDTSIWIDHLHVAEHRLVGRLTNDEIGCHQMVIEELALGMIKQRDDVLRLLSQLREFPLLTHAEILHLVDRRRLWGR
GLSAIDAHLLGSVAVVDGARLWTRDKKLKAACREVGVAIVDES

Download         Length: 372 bp

>T38185 NZ_AP024240:1534526-1534897 [Mycobacterium paraintracellulare]
GTGATCCTCGTTGACACATCGATATGGATTGACCATCTGCACGTCGCCGAGCATCGCCTCGTCGGCCGCTTGACCAACGA
CGAAATCGGTTGCCACCAAATGGTGATCGAGGAGCTGGCACTCGGTATGATCAAGCAGCGCGACGACGTACTGAGATTGC
TGTCCCAGCTGCGCGAGTTTCCGTTGTTGACGCACGCGGAAATCCTCCATCTCGTTGACCGTCGCCGCTTGTGGGGAAGG
GGATTGAGCGCAATCGACGCCCACCTTCTTGGGTCGGTTGCTGTCGTCGACGGTGCACGGCTTTGGACGAGGGACAAGAA
GTTGAAAGCGGCGTGTAGAGAAGTGGGCGTTGCGATCGTCGATGAGTCGTGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7250.31 Da        Isoelectric Point: 11.9169

>AT38185 WP_026071432.1 NZ_AP024240:1534333-1534539 [Mycobacterium paraintracellulare]
MRTTVTIDDALLAQAAELTGVTESAALLRQGLQTLIRVESARRLAALGGTDPKASAAPRRRPPTRDPR

Download         Length: 207 bp

>AT38185 NZ_AP024240:1534333-1534539 [Mycobacterium paraintracellulare]
ATGAGGACAACAGTGACCATCGACGATGCCTTACTGGCTCAGGCGGCGGAACTGACCGGCGTGACGGAGAGTGCGGCGCT
TCTCCGTCAGGGATTGCAGACCCTCATTCGGGTAGAGAGCGCCCGCCGTCTCGCGGCGCTCGGCGGCACGGACCCCAAGG
CGTCGGCCGCCCCGCGGCGGAGGCCGCCGACCCGTGATCCTCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References