Detailed information of TA system TA038184

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): unclassified/Polyketide_cyc2(toxin)
• Location: 1287209..1287862
• Replicon: chromosome
• Accession: NZ_AP024240
• Organism: Mycobacterium paraintracellulare strain M001

Toxin (Protein)

• Gene name: novel[antitoxin]
• Uniprot ID: -
• Locus tag: MINTM021_RS06440
• Protein ID: WP_008253911.1
• Coordinates: 1287401..1287862 (+)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: novel[toxin]
• Uniprot ID: I2A997
• Locus tag: MINTM021_RS06435
• Protein ID: WP_008253910.1
• Coordinates: 1287209..1287397 (+)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MINTM021_RS06425	1283177..1284759	+	1583	Protein_1268	serine hydrolase	-
MINTM021_RS06430	1284756..1287143	+	2388	WP_014711030.1	cation-translocating P-type ATPase	-
MINTM021_RS06435	1287209..1287397	+	189	WP_008253910.1	antitoxin	Antitoxin
MINTM021_RS06440	1287401..1287862	+	462	WP_008253911.1	SRPBCC family protein	Toxin
MINTM021_RS06445	1287947..1288717	+	771	WP_008253913.1	VOC family protein	-
MINTM021_RS06450	1288791..1289225	+	435	WP_008253914.1	hypothetical protein	-
MINTM021_RS06455	1289230..1289718	-	489	WP_008253915.1	glyoxalase/bleomycin resistance/dioxygenase family protein	-
MINTM021_RS06460	1289718..1291244	-	1527	WP_202377960.1	carotenoid oxygenase family protein	-
MINTM021_RS06465	1291246..1292466	-	1221	WP_009957327.1	acetyl-CoA acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polyketide cyclase/dehydrase (1-142)

Antitoxin

• Antitoxin Rv0909/MT0933 (4-52)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 16639.20 Da
• Isoelectric Point: 8.5617

>T38184 WP_008253911.1 NZ_AP024240:1287401-1287862 [Mycobacterium paraintracellulare]
MAKLSGSIDVPLPPEVAWQHASDLSRYKDWLTIHRVWRSALPDEIEKGSVVESIVEVKGMPNRIKWTVVRYKPPEGMTLN
GDGVGGVKVKLMAKIQPKGDGSLVSFDVHLGGPALFGPIGMIVAAALRGDIDQSLENFVTVFTRPDPSSNGHR

Nucleotide

• Length: 462 bp

>T38184 NZ_AP024240:1287401-1287862 [Mycobacterium paraintracellulare]
ATGGCCAAGCTTTCCGGATCCATCGATGTCCCGCTGCCGCCCGAGGTGGCCTGGCAGCACGCCTCCGACCTGTCCCGGTA
CAAGGATTGGCTGACCATCCACCGGGTGTGGCGCAGCGCATTGCCCGACGAGATCGAGAAGGGCTCGGTCGTCGAGTCGA
TTGTCGAGGTCAAGGGCATGCCCAACCGGATCAAATGGACGGTCGTGCGCTACAAGCCACCCGAGGGCATGACGCTCAAC
GGCGACGGAGTCGGCGGGGTCAAGGTCAAGCTGATGGCCAAGATCCAGCCCAAAGGGGACGGCTCCCTCGTCAGTTTCGA
CGTGCACCTCGGTGGCCCCGCACTGTTCGGCCCCATCGGCATGATCGTCGCCGCCGCACTGCGCGGCGATATCGACCAGT
CGCTGGAGAACTTCGTGACGGTGTTCACCCGGCCCGATCCGAGCAGCAACGGGCATCGCTGA

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 6797.44 Da
• Isoelectric Point: 4.4702

>AT38184 WP_008253910.1 NZ_AP024240:1287209-1287397 [Mycobacterium paraintracellulare]
MGFLDKAKDLLWQNADKVETAIDKAGEFVDEKTQGKYSDTIHQVQEQAKKAAGAADTGDQQN

Nucleotide

• Length: 189 bp

>AT38184 NZ_AP024240:1287209-1287397 [Mycobacterium paraintracellulare]
ATGGGATTCCTGGACAAGGCCAAGGATCTGTTGTGGCAGAACGCCGACAAGGTCGAGACGGCCATCGACAAGGCAGGCGA
GTTCGTCGACGAAAAGACGCAGGGCAAATACTCCGACACCATTCACCAGGTGCAGGAGCAGGCGAAGAAGGCGGCCGGCG
CCGCGGACACGGGCGACCAGCAGAACTGA

Structures

Antitoxin

• AlphaFold DB: A0A7I7TPT2