Detailed information of TA system TA038178

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 2394023..2394606
• Replicon: chromosome
• Accession: NZ_AP024238
• Organism: Rhodoferax sp. MIZ03

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LDN84_RS11225
• Protein ID: WP_223912587.1
• Coordinates: 2394023..2394403 (-)
• Length: 127 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LDN84_RS11230
• Protein ID: WP_223912589.1
• Coordinates: 2394400..2394606 (-)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDN84_RS11195 (MIZ03_2393)	2389470..2390159	+	690	WP_223912575.1	hypothetical protein	-
LDN84_RS11200 (MIZ03_2394)	2390156..2391115	+	960	WP_223912578.1	diiron oxygenase	-
LDN84_RS11205 (MIZ03_2395)	2391102..2391764	+	663	WP_223912579.1	hypothetical protein	-
LDN84_RS11210 (MIZ03_2396)	2391761..2392672	+	912	WP_223912581.1	fatty acid desaturase	-
LDN84_RS11215 (MIZ03_2397)	2392698..2393300	+	603	WP_223912583.1	nuclear transport factor 2 family protein	-
LDN84_RS11220 (MIZ03_2398)	2393272..2393931	-	660	WP_223912585.1	hypothetical protein	-
LDN84_RS11225 (MIZ03_2399)	2394023..2394403	-	381	WP_223912587.1	VapC toxin family PIN domain ribonuclease	Toxin
LDN84_RS11230 (MIZ03_2400)	2394400..2394606	-	207	WP_223912589.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
LDN84_RS11235 (MIZ03_2401)	2394622..2394834	-	213	WP_223912591.1	hypothetical protein	-
LDN84_RS11240 (MIZ03_2402)	2394850..2395488	+	639	WP_223912594.1	NAD(P)H-dependent oxidoreductase	-
LDN84_RS11245 (MIZ03_2403)	2395731..2396351	+	621	WP_223912597.1	YqiJ family protein	-
LDN84_RS11250 (MIZ03_2404)	2396369..2398033	+	1665	WP_223912600.1	flotillin family protein	-
LDN84_RS11255 (MIZ03_2405)	2398053..2398511	-	459	WP_223912604.1	GNAT family N-acetyltransferase	-
LDN84_RS11260 (MIZ03_2406)	2398561..2399037	-	477	WP_223912607.1	Lrp/AsnC family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin GhoT/OrtT (4-57)

Antitoxin

• Endoribonuclease antitoxin GhoS (5-94)

Sequences

Toxin

Protein

• Length: 127 a.a.
• Molecular weight: 13771.12 Da
• Isoelectric Point: 5.0342

>T38178 WP_223912587.1 NZ_AP024238:c2394403-2394023 [Rhodoferax sp. MIZ03]
MSVLIDTSVWIDHFRNSNDVLIDLIGQDLALTHPMVIAEIACGTPPAPRAQTLSYLGLLQPCKQASLSEVMAFIEREKLY
GLGCGLVDMTLLASTLITPGAELWTLDKRLADLAGRFAVAYRSMLH

Nucleotide

• Length: 381 bp

>T38178 NZ_AP024238:c2394403-2394023 [Rhodoferax sp. MIZ03]
ATGAGCGTGCTTATCGACACCTCGGTGTGGATAGACCACTTTCGAAACAGTAACGATGTGTTGATTGACCTGATCGGGCA
AGACCTTGCGCTCACGCATCCCATGGTCATTGCCGAAATCGCCTGCGGAACACCACCGGCACCACGTGCCCAGACGCTGA
GCTACTTGGGCCTGTTACAGCCGTGCAAGCAGGCGAGCCTGAGCGAGGTCATGGCTTTCATCGAACGCGAAAAGCTGTAT
GGGCTGGGCTGTGGGCTGGTTGACATGACCTTGCTCGCATCCACACTCATCACGCCGGGGGCTGAGTTGTGGACGCTGGA
TAAACGCCTGGCGGACTTGGCTGGGCGGTTTGCTGTGGCCTATCGGTCGATGCTGCATTGA

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7592.67 Da
• Isoelectric Point: 6.3271

>AT38178 WP_223912589.1 NZ_AP024238:c2394606-2394400 [Rhodoferax sp. MIZ03]
MRTTVTIDDTLYEKALEVADPDMDKADIFREAIKTFVRVQAAKRLAALGGSKSEIKDVPRRREEPAAS

Nucleotide

• Length: 207 bp

>AT38178 NZ_AP024238:c2394606-2394400 [Rhodoferax sp. MIZ03]
ATGCGTACCACAGTCACGATTGACGACACCCTCTACGAAAAAGCCCTGGAGGTGGCCGACCCGGATATGGACAAGGCCGA
CATTTTCCGGGAAGCCATCAAGACTTTTGTGCGCGTGCAAGCGGCCAAGCGTCTTGCCGCCTTAGGCGGTTCGAAGTCTG
AAATAAAGGATGTACCGCGCCGCCGGGAAGAGCCCGCTGCGTCATGA