Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2394023..2394606 Replicon chromosome
Accession NZ_AP024238
Organism Rhodoferax sp. MIZ03

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LDN84_RS11225 Protein ID WP_223912587.1
Coordinates 2394023..2394403 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LDN84_RS11230 Protein ID WP_223912589.1
Coordinates 2394400..2394606 (-) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDN84_RS11195 (MIZ03_2393) 2389470..2390159 + 690 WP_223912575.1 hypothetical protein -
LDN84_RS11200 (MIZ03_2394) 2390156..2391115 + 960 WP_223912578.1 diiron oxygenase -
LDN84_RS11205 (MIZ03_2395) 2391102..2391764 + 663 WP_223912579.1 hypothetical protein -
LDN84_RS11210 (MIZ03_2396) 2391761..2392672 + 912 WP_223912581.1 fatty acid desaturase -
LDN84_RS11215 (MIZ03_2397) 2392698..2393300 + 603 WP_223912583.1 nuclear transport factor 2 family protein -
LDN84_RS11220 (MIZ03_2398) 2393272..2393931 - 660 WP_223912585.1 hypothetical protein -
LDN84_RS11225 (MIZ03_2399) 2394023..2394403 - 381 WP_223912587.1 VapC toxin family PIN domain ribonuclease Toxin
LDN84_RS11230 (MIZ03_2400) 2394400..2394606 - 207 WP_223912589.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LDN84_RS11235 (MIZ03_2401) 2394622..2394834 - 213 WP_223912591.1 hypothetical protein -
LDN84_RS11240 (MIZ03_2402) 2394850..2395488 + 639 WP_223912594.1 NAD(P)H-dependent oxidoreductase -
LDN84_RS11245 (MIZ03_2403) 2395731..2396351 + 621 WP_223912597.1 YqiJ family protein -
LDN84_RS11250 (MIZ03_2404) 2396369..2398033 + 1665 WP_223912600.1 flotillin family protein -
LDN84_RS11255 (MIZ03_2405) 2398053..2398511 - 459 WP_223912604.1 GNAT family N-acetyltransferase -
LDN84_RS11260 (MIZ03_2406) 2398561..2399037 - 477 WP_223912607.1 Lrp/AsnC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13771.12 Da        Isoelectric Point: 5.0342

>T38178 WP_223912587.1 NZ_AP024238:c2394403-2394023 [Rhodoferax sp. MIZ03]
MSVLIDTSVWIDHFRNSNDVLIDLIGQDLALTHPMVIAEIACGTPPAPRAQTLSYLGLLQPCKQASLSEVMAFIEREKLY
GLGCGLVDMTLLASTLITPGAELWTLDKRLADLAGRFAVAYRSMLH

Download         Length: 381 bp

>T38178 NZ_AP024238:c2394403-2394023 [Rhodoferax sp. MIZ03]
ATGAGCGTGCTTATCGACACCTCGGTGTGGATAGACCACTTTCGAAACAGTAACGATGTGTTGATTGACCTGATCGGGCA
AGACCTTGCGCTCACGCATCCCATGGTCATTGCCGAAATCGCCTGCGGAACACCACCGGCACCACGTGCCCAGACGCTGA
GCTACTTGGGCCTGTTACAGCCGTGCAAGCAGGCGAGCCTGAGCGAGGTCATGGCTTTCATCGAACGCGAAAAGCTGTAT
GGGCTGGGCTGTGGGCTGGTTGACATGACCTTGCTCGCATCCACACTCATCACGCCGGGGGCTGAGTTGTGGACGCTGGA
TAAACGCCTGGCGGACTTGGCTGGGCGGTTTGCTGTGGCCTATCGGTCGATGCTGCATTGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7592.67 Da        Isoelectric Point: 6.3271

>AT38178 WP_223912589.1 NZ_AP024238:c2394606-2394400 [Rhodoferax sp. MIZ03]
MRTTVTIDDTLYEKALEVADPDMDKADIFREAIKTFVRVQAAKRLAALGGSKSEIKDVPRRREEPAAS

Download         Length: 207 bp

>AT38178 NZ_AP024238:c2394606-2394400 [Rhodoferax sp. MIZ03]
ATGCGTACCACAGTCACGATTGACGACACCCTCTACGAAAAAGCCCTGGAGGTGGCCGACCCGGATATGGACAAGGCCGA
CATTTTCCGGGAAGCCATCAAGACTTTTGTGCGCGTGCAAGCGGCCAAGCGTCTTGCCGCCTTAGGCGGTTCGAAGTCTG
AAATAAAGGATGTACCGCGCCGCCGGGAAGAGCCCGCTGCGTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References