Detailed information of TA system TA038172

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Txe-YefM
• Location: 4219568..4220097
• Replicon: chromosome
• Accession: NZ_AP024237
• Organism: Mycobacterium heckeshornense strain JCM 15655

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MHEC_RS20400
• Protein ID: WP_048892796.1
• Coordinates: 4219568..4219825 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A2G8BK95
• Locus tag: MHEC_RS20405
• Protein ID: WP_048892820.1
• Coordinates: 4219822..4220097 (-)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MHEC_RS20380	4214636..4215868	-	1233	WP_048892792.1	AAA family ATPase	-
MHEC_RS20385	4216171..4216518	+	348	WP_048892793.1	DUF732 domain-containing protein	-
MHEC_RS20390	4216658..4219087	+	2430	WP_048892794.1	AAA family ATPase	-
MHEC_RS20395	4219084..4219428	+	345	WP_048892795.1	hypothetical protein	-
MHEC_RS20400	4219568..4219825	-	258	WP_048892796.1	Txe/YoeB family addiction module toxin	Toxin
MHEC_RS20405	4219822..4220097	-	276	WP_048892820.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MHEC_RS20410	4220652..4224029	-	3378	WP_200902202.1	TM0106 family RecB-like putative nuclease	-
MHEC_RS20415	4224622..4225059	+	438	Protein_4030	IS30 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-71)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10110.50 Da
• Isoelectric Point: 8.9234

>T38172 WP_048892796.1 NZ_AP024237:c4219825-4219568 [Mycobacterium heckeshornense]
VRSICFDPDAWEDFLFWLASDRKTARRVVRLIAEIQQDPFTGIGKPQPLKGELSGYWSRRIDDQHRLVYRADDTEVKVLK
ARYHY

Nucleotide

• Length: 258 bp

>T38172 NZ_AP024237:c4219825-4219568 [Mycobacterium heckeshornense]
GTGAGAAGCATCTGCTTCGACCCGGACGCCTGGGAGGACTTCCTGTTCTGGCTGGCCTCCGACCGTAAAACCGCCCGCCG
CGTCGTCCGCCTCATCGCCGAGATCCAACAGGATCCGTTCACCGGGATCGGCAAACCCCAACCGCTGAAAGGAGAACTGT
CCGGATACTGGTCGCGCCGCATCGACGACCAACACCGGCTGGTCTACCGGGCAGACGACACAGAAGTCAAAGTGCTCAAG
GCGCGATACCACTACTAA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10193.31 Da
• Isoelectric Point: 5.0981

>AT38172 WP_048892820.1 NZ_AP024237:c4220097-4219822 [Mycobacterium heckeshornense]
VSISASEARQRLFPLLEQVNTDHEPVRITSRAGDAVLMSADDYDSWQETVYLLRSPENARRLMEAVARDKSGHPVHSTSI
NELREMAGGQQ

Nucleotide

• Length: 276 bp

>AT38172 NZ_AP024237:c4220097-4219822 [Mycobacterium heckeshornense]
GTGAGCATCAGCGCAAGTGAAGCCCGCCAACGCCTGTTTCCTCTGCTGGAGCAAGTCAACACCGATCACGAGCCCGTGCG
CATCACCTCCCGGGCCGGAGACGCGGTGCTGATGTCGGCCGACGACTACGACTCGTGGCAAGAGACGGTGTATCTGTTGC
GCTCACCAGAAAACGCCCGGCGGTTGATGGAAGCCGTCGCCCGCGACAAATCCGGACACCCGGTACACAGCACATCGATA
AACGAGCTGAGGGAGATGGCCGGCGGCCAGCAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A2G8BK95