Detailed information of TA system TA038169

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataRT/DUF1778(antitoxin)
• Location: 2345201..2345955
• Replicon: chromosome
• Accession: NZ_AP024233
• Organism: Desulfolithobacter dissulfuricans strain GF1

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: -
• Locus tag: GF1_RS10385
• Protein ID: WP_267926484.1
• Coordinates: 2345467..2345955 (+)
• Length: 163 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: -
• Locus tag: GF1_RS10380
• Protein ID: WP_267926483.1
• Coordinates: 2345201..2345479 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GF1_RS10365 (GF1_21030)	2340492..2340746	-	255	WP_267926480.1	toxin-antitoxin system HicB family antitoxin	-
GF1_RS10370 (GF1_21040)	2341413..2342945	+	1533	WP_267926481.1	Fic family protein	-
GF1_RS10375 (GF1_21050)	2343916..2345076	+	1161	WP_267926482.1	ATP-binding protein	-
GF1_RS10380 (GF1_21060)	2345201..2345479	+	279	WP_267926483.1	DUF1778 domain-containing protein	Antitoxin
GF1_RS10385 (GF1_21070)	2345467..2345955	+	489	WP_267926484.1	GNAT family N-acetyltransferase	Toxin
GF1_RS10390 (GF1_21080)	2346389..2346667	+	279	WP_267926485.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
GF1_RS10395 (GF1_21090)	2346651..2346950	+	300	WP_267926486.1	type II toxin-antitoxin system RelE/ParE family toxin	-
GF1_RS10400 (GF1_21100)	2347691..2349595	-	1905	WP_267926487.1	nucleoside-diphosphate sugar epimerase/dehydratase	-
GF1_RS10405 (GF1_21110)	2349645..2349908	-	264	WP_267926488.1	type II toxin-antitoxin system VapC family toxin	-
GF1_RS10410 (GF1_21120)	2349890..2350099	-	210	WP_267926489.1	hypothetical protein	-
GF1_RS10415 (GF1_21130)	2350099..2350338	-	240	WP_267926490.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2340085..2363430	23345

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (27-145)

Antitoxin

• Vibrio phage ICP1, Orf50 (11-84)

Sequences

Toxin

Protein

• Length: 163 a.a.
• Molecular weight: 17779.85 Da
• Isoelectric Point: 10.6432

>T38169 WP_267926484.1 NZ_AP024233:2345467-2345955 [Desulfolithobacter dissulfuricans]
MGEITAPEPITSAHILADFDCGVSSLNDWLKRQALKNEVSGASRTFVACKDLQVIGFYALAAGSVIRRQAPGKSKRKMPE
PIPVMVLGRLAVDFRWQKNGIGRGLLKDAVLRTIQAAKYAGMRALVVHALSEESRKFYLRHGFLESPLNQFTLMLPSGGV
KI

Nucleotide

• Length: 489 bp

>T38169 NZ_AP024233:2345467-2345955 [Desulfolithobacter dissulfuricans]
ATGGGAGAAATAACCGCGCCGGAACCAATTACCTCGGCGCATATCCTGGCTGATTTCGATTGCGGTGTATCTTCGCTCAA
TGACTGGCTGAAAAGGCAAGCTCTAAAAAATGAAGTGTCCGGGGCTTCCCGGACTTTTGTTGCCTGTAAGGATCTGCAGG
TTATCGGTTTTTACGCATTGGCTGCCGGTAGTGTCATTCGGCGGCAGGCGCCTGGAAAAAGCAAACGTAAAATGCCGGAA
CCAATTCCTGTCATGGTTCTGGGAAGACTGGCAGTGGATTTTCGCTGGCAGAAAAACGGCATTGGCAGGGGGCTGCTGAA
AGATGCCGTTTTGCGAACCATCCAGGCGGCAAAATATGCGGGGATGAGGGCGCTGGTTGTTCATGCGCTGTCTGAAGAAT
CGAGAAAATTTTATCTCCGGCACGGTTTCCTGGAGTCGCCTTTAAACCAGTTCACACTGATGCTGCCATCGGGCGGCGTG
AAAATTTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10415.03 Da
• Isoelectric Point: 5.8625

>AT38169 WP_267926483.1 NZ_AP024233:2345201-2345479 [Desulfolithobacter dissulfuricans]
MAHTETRKAPINIRALDAQRNLIDRAAAILNKNRSEFMLEAACREAENVLLDQRLFLLTEKDFKAFEVALSNPVAENGVM
MDLLASKSPWEK

Nucleotide

• Length: 279 bp

>AT38169 NZ_AP024233:2345201-2345479 [Desulfolithobacter dissulfuricans]
ATGGCACATACGGAAACACGCAAGGCGCCGATCAATATCAGGGCGCTGGACGCACAGCGGAACCTGATTGACAGAGCCGC
TGCCATACTGAACAAAAACCGATCAGAATTCATGCTGGAGGCAGCTTGCCGTGAAGCAGAGAATGTCTTGCTTGATCAAC
GGCTTTTCCTCTTGACGGAGAAAGATTTCAAGGCATTTGAAGTGGCGTTGAGTAACCCTGTCGCCGAAAACGGGGTAATG
ATGGACCTGTTAGCGAGTAAATCCCCATGGGAGAAATAA