Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 1826553..1827134 Replicon chromosome
Accession NZ_AP024233
Organism Desulfolithobacter dissulfuricans strain GF1

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag GF1_RS08105 Protein ID WP_267926025.1
Coordinates 1826835..1827134 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag GF1_RS08100 Protein ID WP_267926024.1
Coordinates 1826553..1826831 (-) Length 93 a.a.

Genomic Context

GF1_RS08070GF1_RS08075GF1_RS08080GF1_RS08085GF1_RS08090GF1_RS08095GF1_RS08110GF1_RS08115GF1_RS08120GF1_RS08125GF1_RS08130GF1_RS08100GF1_RS08105GF1_RS08135
Location: 1821843..1822022 (180 bp)
Type: Others
Protein ID: WP_267926017.1
Location: 1822233..1823624 (1392 bp)
Type: Others
Protein ID: WP_267926018.1
Location: 1823863..1824336 (474 bp)
Type: Others
Protein ID: WP_267926020.1
Location: 1824323..1825378 (1056 bp)
Type: Others
Protein ID: WP_267926021.1
Location: 1825378..1826178 (801 bp)
Type: Others
Protein ID: WP_267926022.1
Location: 1826196..1826456 (261 bp)
Type: Others
Protein ID: WP_267926023.1
Location: 1827184..1827528 (345 bp)
Type: Others
Protein ID: WP_267926026.1
Location: 1827491..1827976 (486 bp)
Type: Others
Protein ID: WP_267926027.1
Location: 1827927..1828838 (912 bp)
Type: Others
Protein ID: WP_267926028.1
Location: 1828817..1829536 (720 bp)
Type: Others
Protein ID: WP_267926029.1
Location: 1829617..1831089 (1473 bp)
Type: Others
Protein ID: WP_267926030.1
Location: 1826553..1826831 (279 bp)
Type: Antitoxin
Protein ID: WP_267926024.1
Location: 1826835..1827134 (300 bp)
Type: Toxin
Protein ID: WP_267926025.1
Location: 1831325..1832134 (810 bp)
Type: Others
Protein ID: WP_267926031.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GF1_RS08070 (GF1_16370)1821843..1822022+180WP_267926017.1hypothetical protein-
GF1_RS08075 (GF1_16380)1822233..1823624+1392WP_267926018.1transposase-
GF1_RS08080 (GF1_16390)1823863..1824336+474WP_267926020.1hypothetical protein-
GF1_RS08085 (GF1_16400)1824323..1825378+1056WP_267926021.1TraU family protein-
GF1_RS08090 (GF1_16410)1825378..1826178+801WP_267926022.1type-F conjugative transfer system pilin assembly protein TrbC-
GF1_RS08095 (GF1_16420)1826196..1826456+261WP_267926023.1hypothetical protein-
GF1_RS08100 (GF1_16430)1826553..1826831-279WP_267926024.1putative addiction module antidote proteinAntitoxin
GF1_RS08105 (GF1_16440)1826835..1827134-300WP_267926025.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GF1_RS08110 (GF1_16450)1827184..1827528+345WP_267926026.1hypothetical protein-
GF1_RS08115 (GF1_16460)1827491..1827976+486WP_267926027.1S26 family signal peptidase-
GF1_RS08120 (GF1_16470)1827927..1828838+912WP_267926028.1conjugal transfer protein TraF-
GF1_RS08125 (GF1_16480)1828817..1829536+720WP_267926029.1hypothetical protein-
GF1_RS08130 (GF1_16490)1829617..1831089+1473WP_267926030.1conjugal transfer protein TraH-
GF1_RS08135 (GF1_16500)1831325..1832134-810WP_267926031.1CsgG/HfaB family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--1781020..1916375135355


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11524.21 Da        Isoelectric Point: 9.6757

>T38168 WP_267926025.1 NZ_AP024233:c1827134-1826835 [Desulfolithobacter dissulfuricans]
MEYTLRSTKEYDKWFARLKDSQAKIRILARLSRVENGNFGDYKPLGPNLFELRFFFGPGWRIYYTIKNNSVVLLLVGGEK
SSQEKNIAKATELLSELED

Download         Length: 300 bp

>T38168 NZ_AP024233:c1827134-1826835 [Desulfolithobacter dissulfuricans]
ATGGAATACACGTTGCGCAGCACAAAAGAATACGACAAGTGGTTTGCCAGGTTGAAGGACTCCCAAGCCAAAATCAGGAT
ACTGGCCAGGCTCAGCCGAGTTGAAAACGGCAATTTTGGAGACTACAAGCCGCTTGGTCCCAATCTGTTTGAGCTGCGTT
TCTTTTTTGGCCCAGGCTGGCGCATTTATTACACCATCAAGAACAATAGCGTTGTTTTGTTGTTGGTTGGTGGCGAAAAA
TCGAGCCAGGAAAAAAACATTGCCAAAGCTACAGAGCTTTTATCCGAACTGGAGGATTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9907.53 Da        Isoelectric Point: 9.7179

>AT38168 WP_267926024.1 NZ_AP024233:c1826831-1826553 [Desulfolithobacter dissulfuricans]
MALKTKPFDIAEHLKTAEDIRLFLQEVAATGDEADFIHALSIAARAKGMTEIAKKAGVTRASLYKSLSEDGNPRFTTISK
ITKALGCKLSIA

Download         Length: 279 bp

>AT38168 NZ_AP024233:c1826831-1826553 [Desulfolithobacter dissulfuricans]
ATGGCCCTTAAAACAAAACCTTTTGACATTGCCGAACATTTGAAGACTGCTGAGGATATTCGCCTTTTCTTGCAGGAGGT
AGCTGCTACCGGAGACGAAGCCGACTTTATCCATGCCCTGAGTATTGCAGCAAGGGCGAAAGGGATGACCGAAATAGCCA
AAAAAGCAGGGGTCACCAGAGCCAGTCTGTACAAATCTCTATCCGAAGATGGCAATCCAAGATTCACTACCATCAGCAAG
ATCACAAAAGCGCTTGGCTGCAAACTATCCATTGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References