Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1872258..1873089 Replicon chromosome
Accession NZ_AP024205
Organism Escherichia coli strain TA8571

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag JG732_RS09035 Protein ID WP_000854814.1
Coordinates 1872258..1872632 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag JG732_RS09040 Protein ID WP_001285585.1
Coordinates 1872721..1873089 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG732_RS08995 1867653..1868819 + 1167 WP_001375226.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
JG732_RS09000 1868938..1869411 + 474 WP_001105414.1 DNA gyrase inhibitor SbmC -
JG732_RS09005 1869610..1870668 + 1059 WP_001200891.1 FUSC family protein -
JG732_RS09010 1870840..1871169 + 330 WP_000450409.1 DUF496 family protein -
JG732_RS09015 1871270..1871452 - 183 WP_001016348.1 hypothetical protein -
JG732_RS09020 1871524..1871652 + 129 Protein_1767 transposase domain-containing protein -
JG732_RS09025 1871941..1872054 - 114 WP_032215426.1 DUF957 domain-containing protein -
JG732_RS09030 1872067..1872261 - 195 WP_000988600.1 hypothetical protein -
JG732_RS09035 1872258..1872632 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
JG732_RS09040 1872721..1873089 - 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
JG732_RS09045 1873163..1873384 - 222 WP_000692323.1 DUF987 domain-containing protein -
JG732_RS09050 1873447..1873923 - 477 WP_001186726.1 RadC family protein -
JG732_RS09055 1873939..1874418 - 480 WP_000860076.1 antirestriction protein -
JG732_RS09060 1874500..1875318 - 819 WP_001234728.1 DUF945 domain-containing protein -
JG732_RS09065 1875538..1875948 - 411 WP_000846713.1 hypothetical protein -
JG732_RS09070 1875964..1876074 - 111 Protein_1777 DNA polymerase III subunit gamma/tau -
JG732_RS09075 1876160..1876906 - 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T38155 WP_000854814.1 NZ_AP024205:c1872632-1872258 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T38155 NZ_AP024205:c1872632-1872258 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT38155 WP_001285585.1 NZ_AP024205:c1873089-1872721 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT38155 NZ_AP024205:c1873089-1872721 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGGGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References