Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 778755..779553 Replicon chromosome
Accession NZ_AP024205
Organism Escherichia coli strain TA8571

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag JG732_RS03825 Protein ID WP_000854735.1
Coordinates 778755..779132 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M1EW42
Locus tag JG732_RS03830 Protein ID WP_032153712.1
Coordinates 779179..779553 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG732_RS03795 774720..775985 - 1266 WP_001218862.1 integrase arm-type DNA-binding domain-containing protein -
JG732_RS03800 776449..776775 - 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
JG732_RS03805 776772..777035 - 264 WP_025492088.1 type II toxin-antitoxin system ParD family antitoxin -
JG732_RS03810 777107..777973 - 867 WP_032153714.1 DUF4942 domain-containing protein -
JG732_RS03815 778058..778255 - 198 WP_000839265.1 DUF957 domain-containing protein -
JG732_RS03820 778267..778758 - 492 WP_023155722.1 hypothetical protein -
JG732_RS03825 778755..779132 - 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
JG732_RS03830 779179..779553 - 375 WP_032153712.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
JG732_RS03835 779633..779854 - 222 WP_000692345.1 DUF987 domain-containing protein -
JG732_RS03840 779923..780399 - 477 WP_001186715.1 RadC family protein -
JG732_RS03845 780415..780900 - 486 WP_032153711.1 antirestriction protein -
JG732_RS03850 780992..781810 - 819 WP_001234693.1 DUF945 domain-containing protein -
JG732_RS03855 781901..782110 - 210 WP_023155727.1 DUF905 family protein -
JG732_RS03860 782140..782817 - 678 WP_023155728.1 hypothetical protein -
JG732_RS03865 782936..783820 - 885 WP_024166630.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR papI / papB 776449..843930 67481


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T38151 WP_000854735.1 NZ_AP024205:c779132-778755 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T38151 NZ_AP024205:c779132-778755 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13697.51 Da        Isoelectric Point: 6.6240

>AT38151 WP_032153712.1 NZ_AP024205:c779553-779179 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT38151 NZ_AP024205:c779553-779179 [Escherichia coli]
GTGTCAGACACTCTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A1M1EW42

References