Detailed information of TA system TA038145

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 2701143..2701919
• Replicon: chromosome
• Accession: NZ_AP024203
• Organism: Staphylococcus aureus strain SA23-1

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: SA231_RS13370
• Protein ID: WP_000031109.1
• Coordinates: 2701143..2701295 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: SA231_RS13375
• Protein ID: WP_001251224.1
• Coordinates: 2701320..2701919 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SA231_RS13355 (2697067)	2697067..2697888	+	822	WP_000669377.1	RluA family pseudouridine synthase	-
SA231_RS13360 (2698345)	2698345..2699730	-	1386	WP_000116239.1	class II fumarate hydratase	-
SA231_RS13365 (2699926)	2699926..2700321	-	396	WP_000901019.1	hypothetical protein	-
SA231_RS13370 (2701143)	2701143..2701295	-	153	WP_000031109.1	SAS053 family protein	Toxin
SA231_RS13375 (2701320)	2701320..2701919	-	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
SA231_RS13380 (2702078)	2702078..2702548	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
SA231_RS13385 (2702553)	2702553..2703680	-	1128	WP_000379990.1	tRNA epoxyqueuosine(34) reductase QueG	-
SA231_RS13390 (2703831)	2703831..2704553	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
SA231_RS13395 (2704546)	2704546..2706003	-	1458	WP_000649917.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5950.31 Da
• Isoelectric Point: 3.9075

>T38145 WP_000031109.1 NZ_AP024203:c2701295-2701143 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEESQ

Nucleotide

• Length: 153 bp

>T38145 NZ_AP024203:c2701295-2701143 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGAGAGTCAGTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT38145 WP_001251224.1 NZ_AP024203:c2701919-2701320 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT38145 NZ_AP024203:c2701919-2701320 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATGTAG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
CAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Structures

Antitoxin

• AlphaFold DB: W8U4V4