Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 2341550..2342338 Replicon chromosome
Accession NZ_AP024203
Organism Staphylococcus aureus strain SA23-1

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag SA231_RS11565 Protein ID WP_000525004.1
Coordinates 2341877..2342338 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag SA231_RS11560 Protein ID WP_000333630.1
Coordinates 2341550..2341864 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SA231_RS11500 (2336692) 2336692..2337858 - 1167 WP_000762547.1 DUF2800 domain-containing protein -
SA231_RS11505 (2337855) 2337855..2338217 - 363 WP_229344986.1 hypothetical protein -
SA231_RS11510 (2338232) 2338232..2338555 - 324 WP_000175001.1 hypothetical protein -
SA231_RS11515 (2338634) 2338634..2338795 - 162 WP_001285954.1 DUF1270 domain-containing protein -
SA231_RS11520 (2338808) 2338808..2339071 - 264 WP_001124160.1 helix-turn-helix domain-containing protein -
SA231_RS11525 (2339096) 2339096..2339311 - 216 WP_001097552.1 hypothetical protein -
SA231_RS11530 (2339366) 2339366..2339731 + 366 WP_001128433.1 hypothetical protein -
SA231_RS11535 (2339700) 2339700..2339945 - 246 WP_001025401.1 DUF2829 domain-containing protein -
SA231_RS11540 (2340001) 2340001..2340210 + 210 WP_000642492.1 hypothetical protein -
SA231_RS11545 (2340200) 2340200..2340343 - 144 WP_000939498.1 hypothetical protein -
SA231_RS11550 (2340372) 2340372..2341148 - 777 WP_001148544.1 Rha family transcriptional regulator -
SA231_RS11555 (2341162) 2341162..2341398 - 237 WP_001121027.1 helix-turn-helix transcriptional regulator -
SA231_RS11560 (2341550) 2341550..2341864 + 315 WP_000333630.1 helix-turn-helix transcriptional regulator Antitoxin
SA231_RS11565 (2341877) 2341877..2342338 + 462 WP_000525004.1 hypothetical protein Toxin
SA231_RS11570 (2342356) 2342356..2342940 + 585 WP_000825948.1 hypothetical protein -
SA231_RS11575 (2343170) 2343170..2343316 + 147 WP_001013104.1 hypothetical protein -
SA231_RS11580 (2343313) 2343313..2343927 - 615 WP_000191459.1 hypothetical protein -
SA231_RS11585 (2344053) 2344053..2345258 + 1206 WP_020444721.1 site-specific integrase -
SA231_RS11590 (2345301) 2345301..2347328 - 2028 WP_229344989.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - gnd 2298645..2367853 69208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T38144 WP_000525004.1 NZ_AP024203:2341877-2342338 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T38144 NZ_AP024203:2341877-2342338 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT38144 WP_000333630.1 NZ_AP024203:2341550-2341864 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT38144 NZ_AP024203:2341550-2341864 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References