Detailed information of TA system TA038139

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1635970..1636447
• Replicon: chromosome
• Accession: NZ_AP024203
• Organism: Staphylococcus aureus strain SA23-1

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: SA231_RS08140
• Protein ID: WP_000052076.1
• Coordinates: 1635970..1636158 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: SA231_RS08145
• Protein ID: WP_001059690.1
• Coordinates: 1636187..1636447 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SA231_RS08110 (1631960)	1631960..1632481	+	522	WP_000824479.1	hypothetical protein	-
SA231_RS08115 (1632822)	1632822..1633508	+	687	WP_001622483.1	thermonuclease family protein	-
SA231_RS08120 (1633865)	1633865..1634065	+	201	WP_001059082.1	cold-shock protein	-
SA231_RS08125 (1634562)	1634562..1634780	-	219	WP_000005875.1	hypothetical protein	-
SA231_RS08130 (1634853)	1634853..1635125	-	273	WP_001004400.1	hypothetical protein	-
SA231_RS08135 (1635213)	1635213..1635782	-	570	WP_001106662.1	lipoprotein N-acylation protein LnsA	-
SA231_RS08140 (1635970)	1635970..1636158	-	189	WP_000052076.1	hypothetical protein	Toxin
SA231_RS08145 (1636187)	1636187..1636447	-	261	WP_001059690.1	hypothetical protein	Antitoxin
SA231_RS08150 (1636788)	1636788..1636991	+	204	WP_000145160.1	sterile alpha motif-like domain-containing protein	-
SA231_RS08155 (1636988)	1636988..1637224	-	237	WP_000368687.1	hypothetical protein	-
SA231_RS08160 (1637448)	1637448..1638029	+	582	WP_061393713.1	histidine phosphatase family protein	-
SA231_RS08165 (1638102)	1638102..1638719	-	618	WP_000255550.1	LysE/ArgO family amino acid transporter	-
SA231_RS08170 (1638875)	1638875..1639369	-	495	WP_000569884.1	GNAT family N-acetyltransferase	-
SA231_RS08175 (1639768)	1639768..1640190	-	423	WP_000974451.1	organic hydroperoxide resistance protein	-
SA231_RS08180 (1640338)	1640338..1641054	+	717	WP_000150033.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	vWbp	1602421..1639369	36948

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T38139 WP_000052076.1 NZ_AP024203:c1636158-1635970 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T38139 NZ_AP024203:c1636158-1635970 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT38139 WP_001059690.1 NZ_AP024203:c1636447-1636187 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT38139 NZ_AP024203:c1636447-1636187 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56