Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 95129..95643 Replicon chromosome
Accession NZ_AP024203
Organism Staphylococcus aureus strain SA23-1

Toxin (Protein)


Gene name TsdT Uniprot ID A0A0U1MQX5
Locus tag SA231_RS00560 Protein ID WP_000581795.1
Coordinates 95129..95338 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0U1MQV0
Locus tag SA231_RS00565 Protein ID WP_000138930.1
Coordinates 95350..95643 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SA231_RS00540 (90637) 90637..91995 - 1359 WP_000611479.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
SA231_RS00545 (92010) 92010..93080 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
SA231_RS00550 (93398) 93398..94600 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
SA231_RS00555 (94864) 94864..95001 - 138 WP_000828354.1 Lmo0850 family protein -
SA231_RS00560 (95129) 95129..95338 - 210 WP_000581795.1 heavy metal-associated domain-containing protein Toxin
SA231_RS00565 (95350) 95350..95643 - 294 WP_000138930.1 copper-sensing transcriptional repressor CsoR Antitoxin
SA231_RS00570 (95809) 95809..97293 + 1485 WP_229345021.1 cardiolipin synthase -
SA231_RS00575 (97321) 97321..97968 + 648 WP_001187625.1 HD domain-containing protein -
SA231_RS00580 (98518) 98518..99390 - 873 WP_000725802.1 membrane protein insertase YidC -
SA231_RS00585 (99476) 99476..100117 - 642 WP_000483162.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7842.83 Da        Isoelectric Point: 4.3869

>T38136 WP_000581795.1 NZ_AP024203:c95338-95129 [Staphylococcus aureus]
MIHQNTIYTAGIETKEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T38136 NZ_AP024203:c95338-95129 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAAAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11169.81 Da        Isoelectric Point: 6.2242

>AT38136 WP_000138930.1 NZ_AP024203:c95643-95350 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVKAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT38136 NZ_AP024203:c95643-95350 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAAAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CATTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1MQX5

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1MQV0

References