Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2089584..2090098 Replicon chromosome
Accession NZ_AP024201
Organism Staphylococcus argenteus strain Tokyo13069

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7JQI0
Locus tag JN167_RS09995 Protein ID WP_000233591.1
Coordinates 2089584..2089793 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag JN167_RS10000 Protein ID WP_000138934.1
Coordinates 2089805..2090098 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN167_RS09975 2084917..2086281 - 1365 WP_047528499.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
JN167_RS09980 2086296..2087366 - 1071 WP_047528497.1 D-alanine--D-alanine ligase -
JN167_RS09985 2087685..2088887 + 1203 WP_047528495.1 rod shape-determining protein RodA -
JN167_RS09990 2089318..2089455 - 138 WP_000828355.1 hypothetical protein -
JN167_RS09995 2089584..2089793 - 210 WP_000233591.1 heavy-metal-associated domain-containing protein Toxin
JN167_RS10000 2089805..2090098 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
JN167_RS10005 2090266..2091750 + 1485 WP_000571570.1 cardiolipin synthase -
JN167_RS10010 2091779..2092426 + 648 WP_047528488.1 HD domain-containing protein -
JN167_RS10015 2092494..2092649 + 156 WP_179077739.1 hypothetical protein -
JN167_RS10020 2093080..2093949 - 870 WP_000725805.1 membrane protein insertase YidC -
JN167_RS10025 2094035..2094676 - 642 WP_047528485.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7827.81 Da        Isoelectric Point: 4.2681

>T38128 WP_000233591.1 NZ_AP024201:c2089793-2089584 [Staphylococcus argenteus]
MVHQNTIYTAGIETEEQVNQLTERISNMIGVHKVNINIIDGEVVVAYETPANLNSIEKEIYDTGYKIVY

Download         Length: 210 bp

>T38128 NZ_AP024201:c2089793-2089584 [Staphylococcus argenteus]
ATGGTACATCAAAACACAATATATACTGCAGGTATTGAAACTGAAGAACAAGTAAACCAGTTGACAGAACGTATATCAAA
CATGATAGGTGTGCATAAAGTGAATATTAATATCATTGATGGAGAAGTAGTTGTAGCATATGAAACACCCGCAAATTTAA
ATAGCATTGAAAAAGAAATTTATGATACAGGCTATAAAATTGTATATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT38128 WP_000138934.1 NZ_AP024201:c2090098-2089805 [Staphylococcus argenteus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT38128 NZ_AP024201:c2090098-2089805 [Staphylococcus argenteus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATTAAAACAAATCTTAAATCACGTTTAAATCGAATAGAAGGTCA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTTCTTACACAAATAAGAGCGACGCGTTCTG
CATTAAACAGTGTCGCAACAAAGTTATTAGAGCAACATATGAAAAGTTGTATTATGAATAAAGTAAATCAAGGTGCTCAA
GAAGAAGCGATGGAAGAGCTACTAGTTACTTTTCAAAAGTTGATTAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7JQI0

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References