Detailed information of TA system TA038127

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2068494..2069023
• Replicon: chromosome
• Accession: NZ_AP024201
• Organism: Staphylococcus argenteus strain Tokyo13069

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: JN167_RS09895
• Protein ID: WP_047528533.1
• Coordinates: 2068494..2068856 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: JN167_RS09900
• Protein ID: WP_000948331.1
• Coordinates: 2068853..2069023 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN167_RS09875	2065476..2066246	-	771	WP_001041104.1	RNA polymerase sigma factor SigB	-
JN167_RS09880	2066221..2066700	-	480	WP_001190826.1	anti-sigma B factor RsbW	-
JN167_RS09885	2066702..2067028	-	327	WP_001052491.1	anti-sigma factor antagonist	-
JN167_RS09890	2067145..2068146	-	1002	WP_000390825.1	PP2C family protein-serine/threonine phosphatase	-
JN167_RS09895	2068494..2068856	-	363	WP_047528533.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
JN167_RS09900	2068853..2069023	-	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
JN167_RS09905	2069108..2070256	-	1149	WP_047528530.1	alanine racemase	-
JN167_RS09910	2070326..2070685	-	360	WP_000581192.1	holo-ACP synthase	-
JN167_RS09915	2070689..2071192	-	504	WP_047528524.1	PH domain-containing protein	-
JN167_RS09920	2071179..2072771	-	1593	WP_047528522.1	PH domain-containing protein	-
JN167_RS09925	2072764..2073243	-	480	WP_047528519.1	PH domain-containing protein	-
JN167_RS09930	2073476..2073994	-	519	Protein_1912	transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13488.72 Da
• Isoelectric Point: 10.1909

>T38127 WP_047528533.1 NZ_AP024201:c2068856-2068494 [Staphylococcus argenteus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDNKMNEVDNALMISLGLNTMAHQKN

Nucleotide

• Length: 363 bp

>T38127 NZ_AP024201:c2068856-2068494 [Staphylococcus argenteus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTTGT
CATTATTCAAAATGACACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCCA
AAATACCGACCCATGTAGAGATTGAAAAGAAAAAATATAAACTGGATAAAGATTCAGTTATATTATTAGAACAAATTCGG
ACACTTGATAAAAAACGTTTAAAAGAAAAACTGACGTACTTATCAGACAACAAAATGAATGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTAAACACAATGGCTCATCAGAAAAATTAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT38127 WP_000948331.1 NZ_AP024201:c2069023-2068853 [Staphylococcus argenteus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT38127 NZ_AP024201:c2069023-2068853 [Staphylococcus argenteus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCAATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1