Detailed information of TA system TA038126

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1876373..1877160
• Replicon: chromosome
• Accession: NZ_AP024201
• Organism: Staphylococcus argenteus strain Tokyo13069

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: A0A7U7PZK3
• Locus tag: JN167_RS08760
• Protein ID: WP_000031103.1
• Coordinates: 1876373..1876528 (-)
• Length: 52 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: JN167_RS08765
• Protein ID: WP_047526976.1
• Coordinates: 1876561..1877160 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN167_RS08740	1871566..1872678	-	1113	WP_031787927.1	GAF domain-containing sensor histidine kinase	-
JN167_RS08745	1872840..1873661	+	822	WP_000669386.1	RluA family pseudouridine synthase	-
JN167_RS08750	1873952..1875337	-	1386	WP_047526974.1	class II fumarate hydratase	-
JN167_RS08755	1875508..1875909	-	402	WP_047526975.1	hypothetical protein	-
JN167_RS08760	1876373..1876528	-	156	WP_000031103.1	hypothetical protein	Toxin
JN167_RS08765	1876561..1877160	-	600	WP_047526976.1	glucosamine-6-phosphate isomerase	Antitoxin
JN167_RS08770	1877319..1877789	-	471	WP_000181399.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
JN167_RS08775	1877791..1878921	-	1131	WP_047430471.1	tRNA epoxyqueuosine(34) reductase QueG	-
JN167_RS08780	1879072..1879794	-	723	WP_047526977.1	amino acid ABC transporter ATP-binding protein	-
JN167_RS08785	1879787..1881244	-	1458	WP_000649887.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 6019.42 Da
• Isoelectric Point: 4.1469

>T38126 WP_000031103.1 NZ_AP024201:c1876528-1876373 [Staphylococcus argenteus]
MSKDKDAKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKSTDEKNSH

Nucleotide

• Length: 156 bp

>T38126 NZ_AP024201:c1876528-1876373 [Staphylococcus argenteus]
ATGTCTAAAGATAAAGATGCAAAATTAAATTATCACGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAGATGGAACAAATTTCAGATCAAAATGATCAAGAGAAGAGTACTGATGAAAAGAATAGCCATTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22468.60 Da
• Isoelectric Point: 5.3935

>AT38126 WP_047526976.1 NZ_AP024201:c1877160-1876561 [Staphylococcus argenteus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDNKKSYFEALGV
PASQIYPIAFEKDTIEFISDKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKKEVVEKLYQENGK
TSFEPSDLKSHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT38126 NZ_AP024201:c1877160-1876561 [Staphylococcus argenteus]
ATGGCAATGAACTTTAAAGTATTTGACAACAGTCAACTTGTAGCAGAATATGCTGCAGATATTATTAGAAAACAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTGGATACAGACCAAGCACCAGTATTAGATGAACTAAAGAAAAACGTTG
AGAAACACGCTGTTGATTTTAGTCAAATAAATATTTTAGATTACGACAATAAAAAATCTTATTTTGAAGCATTAGGCGTG
CCAGCAAGTCAAATTTATCCAATTGCGTTTGAAAAAGATACTATTGAATTTATCTCTGACAAAATTAAAACTAAAGAAAA
TAAAGGTAAACTAACATTACAAGTTGTTTCTATTGATGAGCAAGGAAAATTAAATGTTAGTATCCGCCAAGGTTTAATGG
AAGCAAGAGAAATATTTTTAGTTGTGACAGGTGCTAATAAAAAGGAAGTTGTTGAAAAATTATACCAAGAAAATGGTAAA
ACAAGTTTCGAACCATCTGACTTAAAATCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTCAAAGCTTACTTTACATCTCGCTTTGCTTAA

Structures

Toxin

• AlphaFold DB: A0A7U7PZK3