Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 844753..845230 Replicon chromosome
Accession NZ_AP024201
Organism Staphylococcus argenteus strain Tokyo13069

Toxin (Protein)


Gene name TsaT Uniprot ID A0A7U7JTG2
Locus tag JN167_RS03950 Protein ID WP_000172413.1
Coordinates 844753..844941 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID A0A7U7JTE3
Locus tag JN167_RS03955 Protein ID WP_000790107.1
Coordinates 844970..845230 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN167_RS03920 840405..840875 + 471 WP_047526196.1 hypothetical protein -
JN167_RS03925 841218..841886 + 669 WP_047526197.1 thermonuclease family protein -
JN167_RS03930 842250..842450 + 201 WP_001059082.1 cold-shock protein -
JN167_RS03935 843062..843274 - 213 WP_001007088.1 hypothetical protein -
JN167_RS03940 843335..843619 - 285 WP_031788101.1 hypothetical protein -
JN167_RS03945 843708..844277 - 570 WP_000668727.1 hypothetical protein -
JN167_RS03950 844753..844941 - 189 WP_000172413.1 hypothetical protein Toxin
JN167_RS03955 844970..845230 - 261 WP_000790107.1 hypothetical protein Antitoxin
JN167_RS03960 845570..845773 + 204 WP_000145167.1 sterile alpha motif-like domain-containing protein -
JN167_RS03965 845770..846006 - 237 WP_000368686.1 hypothetical protein -
JN167_RS03970 846231..846812 + 582 WP_047526198.1 phosphoglycerate mutase family protein -
JN167_RS03975 846879..847496 - 618 WP_047526199.1 LysE family transporter -
JN167_RS03980 847660..848151 - 492 WP_000695603.1 GNAT family N-acetyltransferase -
JN167_RS03985 848558..848980 - 423 WP_001007646.1 organic hydroperoxide resistance protein -
JN167_RS03990 849129..849848 + 720 WP_047526200.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - seb 810080..850469 40389


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7192.89 Da        Isoelectric Point: 9.9971

>T38121 WP_000172413.1 NZ_AP024201:c844941-844753 [Staphylococcus argenteus]
MTLHFAILFWLALIFIVAGTFIFVLMKKTAKESKKESYLSFAVIFYIFGFAMLIYTLIFGIL

Download         Length: 189 bp

>T38121 NZ_AP024201:c844941-844753 [Staphylococcus argenteus]
ATGACTTTACATTTTGCAATTTTATTTTGGCTAGCATTAATTTTTATCGTTGCTGGTACATTTATATTTGTCTTAATGAA
AAAAACTGCTAAAGAATCTAAAAAAGAATCTTATTTAAGCTTCGCTGTTATTTTCTATATTTTTGGATTCGCAATGCTAA
TTTATACATTAATATTTGGAATTCTTTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10089.30 Da        Isoelectric Point: 4.1927

>AT38121 WP_000790107.1 NZ_AP024201:c845230-844970 [Staphylococcus argenteus]
MKNIQLNAINLVITIIFAIFNIMITYNKDLDDLCWLLPGIIICGSILIVSFTIAMITKFWLSEILFFINIVLVLYYIYPI
FYDFIN

Download         Length: 261 bp

>AT38121 NZ_AP024201:c845230-844970 [Staphylococcus argenteus]
ATGAAAAACATTCAATTAAATGCTATAAATTTAGTTATAACAATCATATTTGCTATCTTTAACATTATGATTACATATAA
CAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGCATTATCATTTGTGGTTCGATACTCATTGTATCGTTTACCATTG
CAATGATTACTAAATTCTGGTTAAGTGAAATATTATTTTTTATTAACATCGTGCTCGTTCTTTATTATATTTATCCAATT
TTTTATGATTTCATTAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7JTG2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7JTE3

References