Detailed information of TA system TA038112

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1876371..1877158
• Replicon: chromosome
• Accession: NZ_AP024200
• Organism: Staphylococcus argenteus strain Tokyo13064

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: A0A7U7PZK3
• Locus tag: JN157_RS08765
• Protein ID: WP_000031103.1
• Coordinates: 1876371..1876526 (-)
• Length: 52 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: JN157_RS08770
• Protein ID: WP_047526976.1
• Coordinates: 1876559..1877158 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN157_RS08745	1871564..1872676	-	1113	WP_031787927.1	GAF domain-containing sensor histidine kinase	-
JN157_RS08750	1872838..1873659	+	822	WP_000669386.1	RluA family pseudouridine synthase	-
JN157_RS08755	1873950..1875335	-	1386	WP_047526974.1	class II fumarate hydratase	-
JN157_RS08760	1875506..1875907	-	402	WP_047526975.1	hypothetical protein	-
JN157_RS08765	1876371..1876526	-	156	WP_000031103.1	hypothetical protein	Toxin
JN157_RS08770	1876559..1877158	-	600	WP_047526976.1	glucosamine-6-phosphate isomerase	Antitoxin
JN157_RS08775	1877317..1877787	-	471	WP_000181399.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
JN157_RS08780	1877789..1878919	-	1131	WP_047430471.1	tRNA epoxyqueuosine(34) reductase QueG	-
JN157_RS08785	1879070..1879792	-	723	WP_047526977.1	amino acid ABC transporter ATP-binding protein	-
JN157_RS08790	1879785..1881242	-	1458	WP_000649887.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 6019.42 Da
• Isoelectric Point: 4.1469

>T38112 WP_000031103.1 NZ_AP024200:c1876526-1876371 [Staphylococcus argenteus]
MSKDKDAKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKSTDEKNSH

Nucleotide

• Length: 156 bp

>T38112 NZ_AP024200:c1876526-1876371 [Staphylococcus argenteus]
ATGTCTAAAGATAAAGATGCAAAATTAAATTATCACGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAGATGGAACAAATTTCAGATCAAAATGATCAAGAGAAGAGTACTGATGAAAAGAATAGCCATTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22468.60 Da
• Isoelectric Point: 5.3935

>AT38112 WP_047526976.1 NZ_AP024200:c1877158-1876559 [Staphylococcus argenteus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDNKKSYFEALGV
PASQIYPIAFEKDTIEFISDKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKKEVVEKLYQENGK
TSFEPSDLKSHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT38112 NZ_AP024200:c1877158-1876559 [Staphylococcus argenteus]
ATGGCAATGAACTTTAAAGTATTTGACAACAGTCAACTTGTAGCAGAATATGCTGCAGATATTATTAGAAAACAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTGGATACAGACCAAGCACCAGTATTAGATGAACTAAAGAAAAACGTTG
AGAAACACGCTGTTGATTTTAGTCAAATAAATATTTTAGATTACGACAATAAAAAATCTTATTTTGAAGCATTAGGCGTG
CCAGCAAGTCAAATTTATCCAATTGCGTTTGAAAAAGATACTATTGAATTTATCTCTGACAAAATTAAAACTAAAGAAAA
TAAAGGTAAACTAACATTACAAGTTGTTTCTATTGATGAGCAAGGAAAATTAAATGTTAGTATCCGCCAAGGTTTAATGG
AAGCAAGAGAAATATTTTTAGTTGTGACAGGTGCTAATAAAAAGGAAGTTGTTGAAAAATTATACCAAGAAAATGGTAAA
ACAAGTTTCGAACCATCTGACTTAAAATCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTCAAAGCTTACTTTACATCTCGCTTTGCTTAA

Structures

Toxin

• AlphaFold DB: A0A7U7PZK3