Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 844751..845228 Replicon chromosome
Accession NZ_AP024200
Organism Staphylococcus argenteus strain Tokyo13064

Toxin (Protein)


Gene name TsaT Uniprot ID A0A7U7JTG2
Locus tag JN157_RS03950 Protein ID WP_000172413.1
Coordinates 844751..844939 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID A0A7U7JTE3
Locus tag JN157_RS03955 Protein ID WP_000790107.1
Coordinates 844968..845228 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN157_RS03920 840403..840873 + 471 WP_047526196.1 hypothetical protein -
JN157_RS03925 841216..841884 + 669 WP_047526197.1 thermonuclease family protein -
JN157_RS03930 842248..842448 + 201 WP_001059082.1 cold-shock protein -
JN157_RS03935 843060..843272 - 213 WP_001007088.1 hypothetical protein -
JN157_RS03940 843333..843617 - 285 WP_031788101.1 hypothetical protein -
JN157_RS03945 843706..844275 - 570 WP_000668727.1 hypothetical protein -
JN157_RS03950 844751..844939 - 189 WP_000172413.1 hypothetical protein Toxin
JN157_RS03955 844968..845228 - 261 WP_000790107.1 hypothetical protein Antitoxin
JN157_RS03960 845568..845771 + 204 WP_000145167.1 sterile alpha motif-like domain-containing protein -
JN157_RS03965 845768..846004 - 237 WP_000368686.1 hypothetical protein -
JN157_RS03970 846229..846810 + 582 WP_047526198.1 phosphoglycerate mutase family protein -
JN157_RS03975 846877..847494 - 618 WP_047526199.1 LysE family transporter -
JN157_RS03980 847658..848149 - 492 WP_000695603.1 GNAT family N-acetyltransferase -
JN157_RS03985 848556..848978 - 423 WP_001007646.1 organic hydroperoxide resistance protein -
JN157_RS03990 849127..849846 + 720 WP_047526200.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - seb 810078..850467 40389


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7192.89 Da        Isoelectric Point: 9.9971

>T38107 WP_000172413.1 NZ_AP024200:c844939-844751 [Staphylococcus argenteus]
MTLHFAILFWLALIFIVAGTFIFVLMKKTAKESKKESYLSFAVIFYIFGFAMLIYTLIFGIL

Download         Length: 189 bp

>T38107 NZ_AP024200:c844939-844751 [Staphylococcus argenteus]
ATGACTTTACATTTTGCAATTTTATTTTGGCTAGCATTAATTTTTATCGTTGCTGGTACATTTATATTTGTCTTAATGAA
AAAAACTGCTAAAGAATCTAAAAAAGAATCTTATTTAAGCTTCGCTGTTATTTTCTATATTTTTGGATTCGCAATGCTAA
TTTATACATTAATATTTGGAATTCTTTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10089.30 Da        Isoelectric Point: 4.1927

>AT38107 WP_000790107.1 NZ_AP024200:c845228-844968 [Staphylococcus argenteus]
MKNIQLNAINLVITIIFAIFNIMITYNKDLDDLCWLLPGIIICGSILIVSFTIAMITKFWLSEILFFINIVLVLYYIYPI
FYDFIN

Download         Length: 261 bp

>AT38107 NZ_AP024200:c845228-844968 [Staphylococcus argenteus]
ATGAAAAACATTCAATTAAATGCTATAAATTTAGTTATAACAATCATATTTGCTATCTTTAACATTATGATTACATATAA
CAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGCATTATCATTTGTGGTTCGATACTCATTGTATCGTTTACCATTG
CAATGATTACTAAATTCTGGTTAAGTGAAATATTATTTTTTATTAACATCGTGCTCGTTCTTTATTATATTTATCCAATT
TTTTATGATTTCATTAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7JTG2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7JTE3

References