Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 211431..211957 Replicon plasmid pKSB1_9A_1
Accession NZ_AP024174
Organism Klebsiella pneumoniae strain KSB1_9A

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag JGR95_RS26770 Protein ID WP_000323025.1
Coordinates 211431..211718 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J5W3H0
Locus tag JGR95_RS26775 Protein ID WP_004196370.1
Coordinates 211718..211957 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGR95_RS26740 207118..207435 - 318 WP_015065519.1 hypothetical protein -
JGR95_RS26745 207450..207800 - 351 WP_032425551.1 hypothetical protein -
JGR95_RS26750 207797..208069 - 273 WP_032425552.1 hypothetical protein -
JGR95_RS26755 208925..210037 - 1113 WP_001300563.1 IS4-like element IS421 family transposase -
JGR95_RS26760 210116..210274 - 159 WP_014343509.1 type I toxin-antitoxin system Hok family toxin -
JGR95_RS26765 210346..211380 + 1035 Protein_217 IS481 family transposase -
JGR95_RS26770 211431..211718 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
JGR95_RS26775 211718..211957 - 240 WP_004196370.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
JGR95_RS26780 212208..212573 + 366 WP_009651956.1 hypothetical protein -
JGR95_RS26785 212617..213354 + 738 WP_008460272.1 HupE/UreJ family protein -
JGR95_RS26790 213368..214057 + 690 WP_004196322.1 hypothetical protein -
JGR95_RS26795 214088..215464 - 1377 Protein_223 chromate efflux transporter -
JGR95_RS26800 215421..216398 - 978 WP_004196334.1 chromate resistance protein -
JGR95_RS26805 216428..216620 + 193 Protein_225 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..252273 252273


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T38106 WP_000323025.1 NZ_AP024174:c211718-211431 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T38106 NZ_AP024174:c211718-211431 [Klebsiella pneumoniae]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9018.43 Da        Isoelectric Point: 4.3894

>AT38106 WP_004196370.1 NZ_AP024174:c211957-211718 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL

Download         Length: 240 bp

>AT38106 NZ_AP024174:c211957-211718 [Klebsiella pneumoniae]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTTGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4QRH4

References