Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4665614..4666130 Replicon chromosome
Accession NZ_AP024173
Organism Klebsiella pneumoniae strain KSB1_9A

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag JGR95_RS22935 Protein ID WP_002886902.1
Coordinates 4665614..4665898 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JGR95_RS22940 Protein ID WP_002886901.1
Coordinates 4665888..4666130 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGR95_RS22910 4661030..4661338 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
JGR95_RS22915 4661423..4661596 + 174 WP_201357870.1 hypothetical protein -
JGR95_RS22920 4661599..4662342 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JGR95_RS22925 4662699..4664837 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
JGR95_RS22930 4665146..4665610 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JGR95_RS22935 4665614..4665898 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JGR95_RS22940 4665888..4666130 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JGR95_RS22945 4666208..4668118 - 1911 WP_004152270.1 BglG family transcription antiterminator -
JGR95_RS22950 4668141..4669295 - 1155 WP_047718309.1 lactonase family protein -
JGR95_RS22955 4669362..4670102 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T38100 WP_002886902.1 NZ_AP024173:c4665898-4665614 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T38100 NZ_AP024173:c4665898-4665614 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT38100 WP_002886901.1 NZ_AP024173:c4666130-4665888 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT38100 NZ_AP024173:c4666130-4665888 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTTTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References