Detailed information of TA system TA038087

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 718264..719039
• Replicon: chromosome
• Accession: NZ_AP024173
• Organism: Klebsiella pneumoniae strain KSB1_9A

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: -
• Locus tag: JGR95_RS03555
• Protein ID: WP_117046505.1
• Coordinates: 718554..719039 (+)
• Length: 162 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: A0A7U2ZSW0
• Locus tag: JGR95_RS03550
• Protein ID: WP_025710477.1
• Coordinates: 718264..718557 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JGR95_RS03530	713472..714074	-	603	WP_004174410.1	short chain dehydrogenase	-
JGR95_RS03535	714172..715083	+	912	WP_004188550.1	LysR family transcriptional regulator	-
JGR95_RS03540	715084..716232	-	1149	WP_114502093.1	PLP-dependent aspartate aminotransferase family protein	-
JGR95_RS03545	716243..717619	-	1377	WP_165453336.1	cystathionine beta-synthase	-
JGR95_RS03550	718264..718557	+	294	WP_025710477.1	DUF1778 domain-containing protein	Antitoxin
JGR95_RS03555	718554..719039	+	486	WP_117046505.1	GNAT family N-acetyltransferase	Toxin
JGR95_RS03560	719218..719670	-	453	WP_080816334.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (41-143)

Antitoxin

• Vibrio phage ICP1, Orf50 (14-88)

Sequences

Toxin

Protein

• Length: 162 a.a.
• Molecular weight: 17627.66 Da
• Isoelectric Point: 8.5144

>T38087 WP_117046505.1 NZ_AP024173:718554-719039 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRMIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Nucleotide

• Length: 486 bp

>T38087 NZ_AP024173:718554-719039 [Klebsiella pneumoniae]
ATGATCTCCGCTCCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTATGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTAGTTAAT
GCCTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10990.61 Da
• Isoelectric Point: 8.6141

>AT38087 WP_025710477.1 NZ_AP024173:718264-718557 [Klebsiella pneumoniae]
MPAANSMTMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPEPN
AALRKTMQTPAPWEQEK

Nucleotide

• Length: 294 bp

>AT38087 NZ_AP024173:718264-718557 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGTATGACGATGAAACGCGAAACCTTGAACCTGCGCATCAAGCCCGCCGAGCGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGCTGGAGGCCGCCCGAGCTGCCGCTGAGGAAGCGTTGA
TTGAGCAACGCATTATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTGGCCCGTCTGGATCAGGCTCCTGAGCCCAAT
GCCGCATTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A7U2ZSW0