Detailed information of TA system TA038084

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): rlegTA/AbiEii-AbiEi
• Location: 4536885..4538338
• Replicon: chromosome
• Accession: NZ_AP024172
• Organism: Alicycliphilus denitrificans strain I51

Toxin (Protein)

• Gene name: rlegT
• Uniprot ID: -
• Locus tag: ALDI51_RS21435
• Protein ID: WP_201396477.1
• Coordinates: 4536885..4537736 (-)
• Length: 284 a.a.

Antitoxin (Protein)

• Gene name: rlegA
• Uniprot ID: -
• Locus tag: ALDI51_RS21440
• Protein ID: WP_201396478.1
• Coordinates: 4537733..4538338 (-)
• Length: 202 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ALDI51_RS21415	4532192..4532974	-	783	WP_106447349.1	IS21-like element helper ATPase IstB	-
ALDI51_RS21420	4532971..4533978	-	1008	WP_201398426.1	IS21 family transposase	-
ALDI51_RS21430	4535515..4536807	-	1293	WP_201396476.1	hypothetical protein	-
ALDI51_RS21435	4536885..4537736	-	852	WP_201396477.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
ALDI51_RS21440	4537733..4538338	-	606	WP_201396478.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
ALDI51_RS21445	4538829..4539170	-	342	WP_201396479.1	chorismate mutase	-
ALDI51_RS21450	4539167..4540666	-	1500	WP_201396480.1	anthranilate synthase component I	-
ALDI51_RS21455	4541009..4542778	+	1770	WP_201396481.1	MCP four helix bundle domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (34-262)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (8-55)

Sequences

Toxin

Protein

• Length: 284 a.a.
• Molecular weight: 30802.52 Da
• Isoelectric Point: 6.8692

>T38084 WP_201396477.1 NZ_AP024172:c4537736-4536885 [Alicycliphilus denitrificans]
MSNSAASIRARLLNVAKAQGVDFNQVLVRFALERILYRLTQSPHANRFLLKGALLFTLWYDMPHRATRDADLLGFGASDL
ESVAQIFREIAAVAVDDGIVFDPASVSVEEIRKEAGYGGVRVVVAGVLAKARCKTQIDVGFGDAVTPGPVDSIYPVLLGD
MPAPRLRAYPSYTVVAEKLHAIALLGMTNSRVKDYFDLSVLLQRETFDTDLLAQAIKATCERRGMVVPAGLPVGLTDEFA
HDSSRQALWQAFVRKNELDPEPLATVVARLRVALEPALNAAAQ

Nucleotide

• Length: 852 bp

>T38084 NZ_AP024172:c4537736-4536885 [Alicycliphilus denitrificans]
ATGAGCAACAGTGCGGCCTCCATTCGTGCTCGCCTGCTCAACGTGGCCAAGGCGCAAGGCGTGGATTTCAATCAGGTTCT
GGTGCGCTTCGCCCTCGAGCGCATTCTCTACCGTTTGACCCAATCGCCGCATGCAAATCGCTTTCTGCTCAAGGGTGCAC
TACTGTTCACGCTTTGGTACGACATGCCGCATCGGGCTACGCGTGACGCCGACCTGCTGGGCTTCGGTGCGAGCGATCTG
GAATCGGTCGCGCAGATCTTTCGTGAGATCGCAGCCGTCGCTGTGGACGACGGCATCGTGTTCGACCCTGCTTCTGTCAG
CGTCGAAGAAATCCGCAAGGAAGCGGGCTATGGCGGCGTGCGCGTGGTCGTTGCAGGCGTTTTGGCCAAGGCACGCTGCA
AGACGCAGATCGACGTCGGCTTTGGAGATGCCGTTACGCCTGGCCCAGTGGACTCGATCTACCCGGTGCTCTTGGGCGAC
ATGCCTGCACCGCGACTACGAGCCTATCCAAGCTACACCGTTGTCGCGGAAAAGCTTCATGCTATTGCGCTGCTGGGCAT
GACGAACAGCCGCGTGAAGGACTACTTCGACCTGTCGGTGCTATTGCAGCGCGAAACCTTCGATACCGATCTGCTGGCCC
AGGCGATCAAGGCCACCTGCGAGCGGCGCGGCATGGTTGTACCCGCCGGACTGCCGGTCGGCCTCACGGACGAATTCGCG
CACGATTCCTCACGGCAGGCACTGTGGCAGGCATTCGTCAGGAAGAACGAACTCGATCCCGAACCGTTGGCCACTGTTGT
GGCTCGGCTGCGGGTGGCGTTGGAACCAGCGTTGAATGCAGCTGCGCAATAG

Antitoxin

Protein

• Length: 202 a.a.
• Molecular weight: 22353.07 Da
• Isoelectric Point: 9.6131

>AT38084 WP_201396478.1 NZ_AP024172:c4538338-4537733 [Alicycliphilus denitrificans]
MVADTHTQRVLDLVHQKGLLRTSDLDAIEAPRVVLTRLISAGLLDKVGRGLYRLPSHEGSEHEGLAVVATKVPQAVFCLL
TALQFHELTTQLPRQVWIAMPRGSHVPRVAYPPLKMVQMTGDVYAAGVEEHQRDGVTLRVYGAAKTVVDCFKHRNKIGLD
VALEALKDARAKKKATADDLWRYAKLCRVANVMRPYLEAIE

Nucleotide

• Length: 606 bp

>AT38084 NZ_AP024172:c4538338-4537733 [Alicycliphilus denitrificans]
ATGGTCGCCGACACCCACACCCAGCGCGTCCTCGATCTGGTTCATCAGAAGGGGCTGCTGCGCACGAGTGATCTGGATGC
CATTGAAGCACCTCGGGTTGTGCTGACGCGGCTGATATCCGCTGGCCTGCTCGACAAGGTCGGACGCGGCCTCTACCGTT
TGCCCAGTCACGAGGGTTCGGAGCATGAGGGCCTTGCCGTTGTGGCAACCAAGGTGCCGCAGGCCGTGTTCTGCCTGCTG
ACCGCCCTCCAGTTCCACGAACTGACCACGCAGCTACCCAGGCAGGTCTGGATTGCCATGCCGCGCGGCAGCCATGTTCC
GCGCGTCGCCTACCCGCCCCTCAAGATGGTGCAGATGACGGGCGATGTCTACGCCGCTGGCGTCGAGGAGCATCAGCGAG
ATGGCGTGACGCTGCGTGTGTACGGTGCGGCTAAGACGGTCGTGGACTGCTTCAAGCACCGCAACAAGATCGGTTTGGAC
GTGGCGCTGGAGGCGCTGAAGGATGCACGCGCCAAGAAAAAGGCCACGGCGGACGATCTGTGGCGCTACGCGAAGCTTTG
CCGCGTGGCCAATGTGATGCGCCCTTATCTAGAAGCCATCGAATGA