Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 4353288..4353970 Replicon chromosome
Accession NZ_AP024172
Organism Alicycliphilus denitrificans strain I51

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ALDI51_RS20575 Protein ID WP_201396356.1
Coordinates 4353527..4353970 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag ALDI51_RS20570 Protein ID WP_094438867.1
Coordinates 4353288..4353530 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ALDI51_RS20550 4349053..4349778 - 726 WP_201396354.1 flagellar assembly protein FliH -
ALDI51_RS20555 4349800..4350795 - 996 WP_201396355.1 flagellar motor switch protein FliG -
ALDI51_RS20560 4350826..4352520 - 1695 WP_094438869.1 flagellar M-ring protein FliF -
ALDI51_RS20565 4352697..4353008 + 312 WP_094438868.1 flagellar hook-basal body complex protein FliE -
ALDI51_RS20570 4353288..4353530 + 243 WP_094438867.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
ALDI51_RS20575 4353527..4353970 + 444 WP_201396356.1 type II toxin-antitoxin system VapC family toxin Toxin
ALDI51_RS20580 4354087..4354386 - 300 WP_094438865.1 flagellar protein FliT -
ALDI51_RS20585 4354390..4354833 - 444 WP_201396357.1 flagellar export chaperone FliS -
ALDI51_RS20590 4354900..4356345 - 1446 WP_201396358.1 flagellar filament capping protein FliD -
ALDI51_RS20595 4356578..4358038 - 1461 WP_201396359.1 flagellin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-126)

Antitoxin

SpoVT-AbrB domain

(10-55)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 15519.83 Da        Isoelectric Point: 6.0706

>T38083 WP_201396356.1 NZ_AP024172:4353527-4353970 [Alicycliphilus denitrificans]
MNAPRYLLDTNILSDLVRHPQGIVARKIAEVGEAAVCTSIIAAAELRFGAAKRNSARLSHQVHAILSAIEVLALDMPADS
AYAQLRWALEQSGRPIGPNGMLIAAQALAHECVLVTANVGEFSRIADLQVTNWLGEAGDPLSAATVA

Download         Length: 444 bp

>T38083 NZ_AP024172:4353527-4353970 [Alicycliphilus denitrificans]
ATGAATGCCCCGCGCTACCTGCTCGACACCAACATCCTCTCCGACCTGGTGCGCCATCCGCAAGGCATCGTGGCCCGCAA
GATTGCAGAGGTTGGAGAGGCGGCCGTATGCACGTCGATCATCGCAGCGGCCGAGTTGCGTTTCGGGGCCGCCAAGCGCA
ACTCCGCCCGACTCTCGCACCAAGTGCATGCCATTTTGTCTGCCATCGAAGTACTGGCGCTCGATATGCCAGCCGATAGC
GCCTACGCGCAACTGCGTTGGGCCCTGGAGCAATCGGGCCGCCCCATCGGCCCCAATGGCATGCTGATCGCCGCCCAGGC
CCTGGCCCATGAGTGCGTGCTGGTCACCGCCAATGTGGGCGAATTTTCCCGGATCGCGGACTTGCAGGTCACCAACTGGC
TCGGAGAAGCGGGCGATCCGCTTTCAGCCGCGACCGTCGCATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9280.45 Da        Isoelectric Point: 4.2392

>AT38083 WP_094438867.1 NZ_AP024172:4353288-4353530 [Alicycliphilus denitrificans]
MFAERHVRLFRNGRNQAVRIPREFELDAQEAIIRREDDRLVIEPVRKQGLLATLATLPALEEDDWDDVDAGLQPLDDIDL

Download         Length: 243 bp

>AT38083 NZ_AP024172:4353288-4353530 [Alicycliphilus denitrificans]
ATGTTCGCCGAACGCCATGTCCGCCTATTTCGCAACGGACGCAATCAGGCCGTGCGCATTCCCCGTGAATTTGAGCTGGA
TGCGCAAGAGGCCATCATCCGGCGGGAGGACGATCGCCTGGTGATCGAACCCGTGCGCAAGCAAGGCCTGCTGGCCACGC
TGGCAACCCTGCCAGCACTCGAAGAAGACGACTGGGACGACGTGGATGCCGGGTTGCAGCCGCTGGACGATATCGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References