Detailed information of TA system TA038082

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 4122757..4123391
• Replicon: chromosome
• Accession: NZ_AP024172
• Organism: Alicycliphilus denitrificans strain I51

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: ALDI51_RS19500
• Protein ID: WP_201396213.1
• Coordinates: 4122987..4123391 (+)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: ALDI51_RS19495
• Protein ID: WP_201396212.1
• Coordinates: 4122757..4122990 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ALDI51_RS19470	4118395..4118814	+	420	WP_201396207.1	hypothetical protein	-
ALDI51_RS19475	4118881..4120227	+	1347	WP_201396208.1	tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB	-
ALDI51_RS19480	4120419..4121180	-	762	WP_201396209.1	hypothetical protein	-
ALDI51_RS19485	4121271..4121795	-	525	WP_201396210.1	pilin	-
ALDI51_RS19490	4122019..4122465	+	447	WP_201396211.1	hypothetical protein	-
ALDI51_RS19495	4122757..4122990	+	234	WP_201396212.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
ALDI51_RS19500	4122987..4123391	+	405	WP_201396213.1	type II toxin-antitoxin system VapC family toxin	Toxin
ALDI51_RS19505	4123465..4124844	-	1380	WP_013722921.1	signal recognition particle protein	-
ALDI51_RS19510	4124934..4125731	+	798	WP_094438286.1	cytochrome c biogenesis protein CcsA	-
ALDI51_RS19515	4125728..4125955	+	228	WP_201396214.1	hypothetical protein	-
ALDI51_RS19520	4125968..4127671	+	1704	WP_094438288.1	HAMP domain-containing histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 14973.42 Da
• Isoelectric Point: 7.0273

>T38082 WP_201396213.1 NZ_AP024172:4122987-4123391 [Alicycliphilus denitrificans]
VMRYMLDTNICIYVINQRPAHVLPIFNAHHSQMCISEITRFELLSGAYKSKAPHKALYDISTFCAMLDVLPLDAAACDHA
AQIRAMLEQKGQKIGPFDTLIAGHARSLAAILVTNNVREFERVGSLMIEDWTQG

Nucleotide

• Length: 405 bp

>T38082 NZ_AP024172:4122987-4123391 [Alicycliphilus denitrificans]
GTGATGCGCTACATGCTCGACACCAACATTTGCATCTACGTCATCAACCAGCGGCCCGCTCATGTGCTGCCCATCTTCAA
TGCGCATCACAGCCAGATGTGCATCTCCGAGATCACGCGTTTCGAGCTTTTGAGCGGCGCCTACAAGTCCAAGGCGCCGC
ACAAGGCCCTGTACGACATCAGTACCTTTTGCGCCATGCTCGATGTGCTGCCACTCGATGCCGCCGCCTGCGACCATGCG
GCGCAGATTCGCGCCATGCTGGAGCAAAAGGGCCAGAAGATCGGCCCCTTCGATACGCTCATCGCGGGCCATGCGCGCAG
CCTCGCCGCCATCCTCGTCACCAACAACGTGCGCGAGTTCGAGCGCGTCGGCAGCCTGATGATCGAGGACTGGACGCAGG
GCTGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8665.89 Da
• Isoelectric Point: 6.2096

>AT38082 WP_201396212.1 NZ_AP024172:4122757-4122990 [Alicycliphilus denitrificans]
MVHSKLFLNHKSQSVRFHKSVAFAPEVQEVTIVAVGNTRIIAPVGKTWDAWFAQPVDDDALLPERDQPPMQEREALA

Nucleotide

• Length: 234 bp

>AT38082 NZ_AP024172:4122757-4122990 [Alicycliphilus denitrificans]
ATGGTCCACTCCAAGCTGTTCCTGAATCACAAGAGCCAGTCCGTCCGCTTTCACAAGTCGGTGGCATTCGCACCCGAGGT
GCAGGAGGTCACCATTGTGGCGGTGGGCAACACCCGCATCATTGCGCCTGTCGGCAAGACCTGGGATGCCTGGTTTGCAC
AGCCGGTGGATGATGACGCCCTGCTGCCCGAGCGCGATCAGCCCCCCATGCAAGAGCGAGAGGCGCTGGCGTGA