Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 2106111..2106649 Replicon chromosome
Accession NZ_AP024170
Organism Staphylococcus aureus strain 834

Toxin (Protein)


Gene name TscT Uniprot ID A0A0H3K0C1
Locus tag SA834_RS10465 Protein ID WP_001078344.1
Coordinates 2106111..2106437 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A0H3JSN0
Locus tag SA834_RS10470 Protein ID WP_001058495.1
Coordinates 2106440..2106649 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SA834_RS10440 2101335..2101676 - 342 WP_001190615.1 hypothetical protein -
SA834_RS10445 2102126..2102767 - 642 WP_001047698.1 hypothetical protein -
SA834_RS10450 2102764..2103144 - 381 WP_000356942.1 hypothetical protein -
SA834_RS10455 2103454..2105163 - 1710 WP_000447473.1 DUF927 domain-containing protein -
SA834_RS10460 2105177..2106046 - 870 WP_001002689.1 primase alpha helix C-terminal domain-containing protein -
SA834_RS10465 2106111..2106437 - 327 WP_001078344.1 DUF1474 family protein Toxin
SA834_RS10470 2106440..2106649 - 210 WP_001058495.1 hypothetical protein Antitoxin
SA834_RS10475 2106642..2106788 - 147 WP_000784885.1 hypothetical protein -
SA834_RS10480 2106785..2107102 - 318 WP_000481967.1 helix-turn-helix domain-containing protein -
SA834_RS10485 2107107..2107325 - 219 WP_000153640.1 helix-turn-helix transcriptional regulator -
SA834_RS10490 2107498..2108172 + 675 WP_000620857.1 helix-turn-helix transcriptional regulator -
SA834_RS10495 2108186..2109358 + 1173 WP_000179343.1 site-specific integrase -
SA834_RS10500 2109427..2111043 - 1617 WP_000240642.1 chaperonin GroEL -
SA834_RS10505 2111119..2111403 - 285 WP_000917289.1 co-chaperone GroES -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / chp / sak / hlb / sell / sec / tsst-1 / groEL 2045229..2111403 66174


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12968.26 Da        Isoelectric Point: 4.3050

>T38073 WP_001078344.1 NZ_AP024170:c2106437-2106111 [Staphylococcus aureus]
MNREIKDLFSDLKLLKDSFEDLKDSNGWHFDELYPYEPNHVLNKDELIGEGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSENFGEESDDAKNSIKVAE

Download         Length: 327 bp

>T38073 NZ_AP024170:c2106437-2106111 [Staphylococcus aureus]
ATGAATCGGGAAATTAAAGATTTATTTAGCGATTTAAAGTTGTTGAAAGATAGTTTTGAGGATTTAAAGGATAGTAATGG
TTGGCATTTTGATGAGCTATATCCATATGAACCAAATCATGTCTTAAATAAAGATGAATTAATTGGAGAGGGATTTTCTT
ATCATGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAGCAGTTCGATAATATTATCGAA
AAGTTTTATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGC
AGAGTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8206.22 Da        Isoelectric Point: 4.3718

>AT38073 WP_001058495.1 NZ_AP024170:c2106649-2106440 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVVNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT38073 NZ_AP024170:c2106649-2106440 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCGTGAATAATTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3K0C1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3JSN0

References