Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 852982..853459 Replicon chromosome
Accession NZ_AP024170
Organism Staphylococcus aureus strain 834

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag SA834_RS04045 Protein ID WP_000052076.1
Coordinates 852982..853170 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SA834_RS04050 Protein ID WP_001059690.1
Coordinates 853199..853459 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SA834_RS04015 848507..849193 + 687 WP_000141557.1 thermonuclease family protein -
SA834_RS04020 849550..849750 + 201 WP_001059082.1 cold-shock protein -
SA834_RS04025 850204..851375 - 1172 Protein_783 IS256-like element IS256 family transposase -
SA834_RS04030 851573..851791 - 219 WP_000005886.1 hypothetical protein -
SA834_RS04035 851853..852137 - 285 WP_001004399.1 hypothetical protein -
SA834_RS04040 852225..852794 - 570 WP_001106654.1 hypothetical protein -
SA834_RS04045 852982..853170 - 189 WP_000052076.1 hypothetical protein Toxin
SA834_RS04050 853199..853459 - 261 WP_001059690.1 hypothetical protein Antitoxin
SA834_RS04055 853800..854003 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SA834_RS04060 854000..854236 - 237 WP_000349581.1 hypothetical protein -
SA834_RS04065 854461..855042 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
SA834_RS04070 855115..855732 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
SA834_RS04075 855887..856381 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
SA834_RS04080 856780..857202 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
SA834_RS04085 857350..858066 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 850509..851375 866


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T38066 WP_000052076.1 NZ_AP024170:c853170-852982 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T38066 NZ_AP024170:c853170-852982 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT38066 WP_001059690.1 NZ_AP024170:c853459-853199 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT38066 NZ_AP024170:c853459-853199 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References