Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 178344..178860 Replicon plasmid pYa108
Accession NZ_AP024168
Organism Vibrio alfacsensis strain 04Ya108

Toxin (Protein)


Gene name relB Uniprot ID -
Locus tag VA249_RS23805 Protein ID WP_221072682.1
Coordinates 178344..178613 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag VA249_RS23810 Protein ID WP_221072456.1
Coordinates 178606..178860 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VA249_RS23785 (VYA_45540) 174152..175213 - 1062 WP_221072448.1 HlyD family secretion protein -
VA249_RS23790 (VYA_45550) 175283..176407 - 1125 WP_221072450.1 AI-2E family transporter -
VA249_RS23795 (VYA_45560) 176683..177699 + 1017 WP_221072452.1 helix-turn-helix domain-containing protein -
VA249_RS23800 (VYA_45570) 177949..178281 + 333 WP_221072454.1 SEC-C metal-binding domain-containing protein -
VA249_RS23805 (VYA_45580) 178344..178613 - 270 WP_221072682.1 Txe/YoeB family addiction module toxin Toxin
VA249_RS23810 (VYA_45590) 178606..178860 - 255 WP_221072456.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
VA249_RS23815 (VYA_45600) 179004..180593 - 1590 WP_221072458.1 amidase -
VA249_RS23820 (VYA_45610) 180595..181473 - 879 WP_221072460.1 SDR family oxidoreductase -
VA249_RS23825 (VYA_45620) 181530..182681 - 1152 WP_221072462.1 acetyl-CoA C-acetyltransferase -
VA249_RS23830 (VYA_45630) 182681..183751 - 1071 WP_221072464.1 acyl-CoA dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..221076 221076


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10684.16 Da        Isoelectric Point: 9.4087

>T38065 WP_221072682.1 NZ_AP024168:c178613-178344 [Vibrio alfacsensis]
MISHQRLLAWTDEAWNDYLYWQNQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLAGFWSRRIDDTNRLVYAVDNQAI
TIISCRYHY

Download         Length: 270 bp

>T38065 NZ_AP024168:c178613-178344 [Vibrio alfacsensis]
ATGATTAGTCACCAGCGTTTGCTCGCTTGGACTGACGAAGCTTGGAATGACTACCTATATTGGCAAAATCAGGACAAGAA
AACACTCAAGCGTATCAATAAATTAATTAATGATGTAAAGCGCTCGCCCTTTGAGGGGATTGGTAAACCAGAGCCTTTAA
AAGAGAACCTGGCTGGTTTCTGGTCACGTCGCATTGATGATACCAATCGTCTCGTTTACGCGGTCGATAACCAGGCGATA
ACCATTATTTCTTGCCGTTACCATTATTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9484.61 Da        Isoelectric Point: 4.7497

>AT38065 WP_221072456.1 NZ_AP024168:c178860-178606 [Vibrio alfacsensis]
MRIVSFTEARNSLKAVLDGVVNDADTTIITRRDSEDAVVMSLDYYNSLMETVHLLRSPENADHLKRSIAQYRAGQVTSRD
LIDD

Download         Length: 255 bp

>AT38065 NZ_AP024168:c178860-178606 [Vibrio alfacsensis]
ATGAGAATCGTATCTTTTACTGAAGCACGAAATAGTTTAAAAGCGGTGTTAGACGGTGTGGTTAATGATGCTGACACGAC
GATCATTACGCGGAGAGACTCAGAAGATGCTGTGGTGATGTCATTAGATTATTACAACAGTTTGATGGAAACGGTGCACT
TACTGCGTTCTCCAGAGAACGCGGATCATCTCAAGCGTTCAATTGCTCAATATCGTGCTGGCCAAGTGACTTCTCGAGAC
TTAATTGATGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References