Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/YafN(antitoxin) |
| Location | 1310601..1311166 | Replicon | chromosome |
| Accession | NZ_AP024165 | ||
| Organism | Vibrio alfacsensis strain 04Ya108 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A853R5G7 |
| Locus tag | VA249_RS06395 | Protein ID | WP_017046277.1 |
| Coordinates | 1310879..1311166 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A2N7N9N2 |
| Locus tag | VA249_RS06390 | Protein ID | WP_025633738.1 |
| Coordinates | 1310601..1310882 (+) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| VA249_RS06355 (VYA_11570) | 1305658..1306158 | + | 501 | WP_221069413.1 | hypothetical protein | - |
| VA249_RS06360 | 1306188..1306278 | + | 91 | Protein_1221 | DUF3265 domain-containing protein | - |
| VA249_RS06365 (VYA_11580) | 1306335..1307717 | - | 1383 | WP_221069415.1 | hypothetical protein | - |
| VA249_RS06370 (VYA_11590) | 1307719..1308918 | - | 1200 | WP_221069417.1 | hypothetical protein | - |
| VA249_RS06375 (VYA_11600) | 1309160..1309408 | + | 249 | WP_225927107.1 | ASCH domain-containing protein | - |
| VA249_RS06380 (VYA_11610) | 1310045..1310392 | + | 348 | WP_203508314.1 | zinc ribbon domain-containing protein | - |
| VA249_RS06385 | 1310418..1310510 | + | 93 | WP_004418565.1 | DUF3265 domain-containing protein | - |
| VA249_RS06390 (VYA_11620) | 1310601..1310882 | + | 282 | WP_025633738.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| VA249_RS06395 (VYA_11630) | 1310879..1311166 | + | 288 | WP_017046277.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| VA249_RS06400 (VYA_11640) | 1311338..1312072 | - | 735 | WP_221069419.1 | hypothetical protein | - |
| VA249_RS06405 (VYA_11650) | 1312299..1312715 | + | 417 | WP_050907381.1 | GNAT family N-acetyltransferase | - |
| VA249_RS06410 (VYA_11660) | 1312874..1313287 | + | 414 | WP_130341096.1 | hypothetical protein | - |
| VA249_RS06415 | 1313324..1313413 | + | 90 | WP_221069840.1 | DUF3265 domain-containing protein | - |
| VA249_RS06420 (VYA_11670) | 1313440..1313955 | + | 516 | WP_221069421.1 | GNAT family N-acetyltransferase | - |
| VA249_RS24075 | 1313956..1314018 | + | 63 | Protein_1234 | DUF3265 domain-containing protein | - |
| VA249_RS24080 | 1313994..1314071 | + | 78 | WP_079884017.1 | DUF3265 domain-containing protein | - |
| VA249_RS06430 (VYA_11680) | 1314105..1314830 | + | 726 | WP_050935566.1 | hypothetical protein | - |
| VA249_RS24085 | 1314845..1314937 | + | 93 | WP_225927108.1 | DUF3265 domain-containing protein | - |
| VA249_RS06435 (VYA_11690) | 1314987..1315457 | + | 471 | WP_065646338.1 | GNAT family N-acetyltransferase | - |
| VA249_RS06440 | 1315487..1315579 | + | 93 | WP_083135941.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1225667..1320873 | 95206 | |
| - | inside | Integron | - | - | 1226253..1318506 | 92253 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10959.63 Da Isoelectric Point: 5.0746
>T38064 WP_017046277.1 NZ_AP024165:1310879-1311166 [Vibrio alfacsensis]
MKVVWSPLALQKLGDAAEFISLDNPVAAENWVNEVFDKTDLLSSMPEMGRMVPELPHTNYREILFGHYRIIYSLSHEIRV
LTVRNCRQILTESDV
MKVVWSPLALQKLGDAAEFISLDNPVAAENWVNEVFDKTDLLSSMPEMGRMVPELPHTNYREILFGHYRIIYSLSHEIRV
LTVRNCRQILTESDV
Download Length: 288 bp
>T38064 NZ_AP024165:1310879-1311166 [Vibrio alfacsensis]
ATGAAAGTAGTTTGGTCACCACTAGCATTACAAAAGTTAGGTGATGCAGCTGAGTTTATTTCACTAGATAATCCAGTGGC
TGCAGAAAACTGGGTTAATGAGGTCTTCGACAAAACAGACCTTCTCTCAAGTATGCCTGAAATGGGGCGAATGGTTCCGG
AGCTACCTCATACTAATTACCGCGAAATCTTGTTTGGTCACTATCGAATCATATATAGCCTCAGCCATGAAATTCGCGTT
CTTACTGTACGAAATTGTCGACAGATATTAACGGAAAGTGACGTGTAG
ATGAAAGTAGTTTGGTCACCACTAGCATTACAAAAGTTAGGTGATGCAGCTGAGTTTATTTCACTAGATAATCCAGTGGC
TGCAGAAAACTGGGTTAATGAGGTCTTCGACAAAACAGACCTTCTCTCAAGTATGCCTGAAATGGGGCGAATGGTTCCGG
AGCTACCTCATACTAATTACCGCGAAATCTTGTTTGGTCACTATCGAATCATATATAGCCTCAGCCATGAAATTCGCGTT
CTTACTGTACGAAATTGTCGACAGATATTAACGGAAAGTGACGTGTAG
Antitoxin
Download Length: 94 a.a. Molecular weight: 10426.96 Da Isoelectric Point: 5.8719
>AT38064 WP_025633738.1 NZ_AP024165:1310601-1310882 [Vibrio alfacsensis]
MSRIHFDQDIQPLSEFRAGVTSFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
EDARAQVLGRLKK
MSRIHFDQDIQPLSEFRAGVTSFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
EDARAQVLGRLKK
Download Length: 282 bp
>AT38064 NZ_AP024165:1310601-1310882 [Vibrio alfacsensis]
ATGAGCCGTATCCATTTTGATCAAGATATTCAGCCTTTGTCTGAATTTCGTGCTGGCGTGACGTCATTTATTAAACAGAT
TAACGAAACTCGCAGACCGCTAGTAATCACACAACGTGGTAAAGGTGTCGCGGTTGTCCTTGATGTTGCGGAATATGAAG
CGATGCAAGAGAAGATCGAGTTACTAGAAGAAATGCGTACTGCTGAAGCACAGTTAGCTTCCGGTTTAGGTGTTTCCAAT
GAAGACGCTCGTGCTCAAGTGTTGGGGCGTCTTAAGAAATGA
ATGAGCCGTATCCATTTTGATCAAGATATTCAGCCTTTGTCTGAATTTCGTGCTGGCGTGACGTCATTTATTAAACAGAT
TAACGAAACTCGCAGACCGCTAGTAATCACACAACGTGGTAAAGGTGTCGCGGTTGTCCTTGATGTTGCGGAATATGAAG
CGATGCAAGAGAAGATCGAGTTACTAGAAGAAATGCGTACTGCTGAAGCACAGTTAGCTTCCGGTTTAGGTGTTTCCAAT
GAAGACGCTCGTGCTCAAGTGTTGGGGCGTCTTAAGAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A853R5G7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2N7N9N2 |