Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/Phd(antitoxin) |
| Location | 1261087..1261634 | Replicon | chromosome |
| Accession | NZ_AP024165 | ||
| Organism | Vibrio alfacsensis strain 04Ya108 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | VA249_RS05890 | Protein ID | WP_221069333.1 |
| Coordinates | 1261332..1261634 (+) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U3A269 |
| Locus tag | VA249_RS05885 | Protein ID | WP_005448240.1 |
| Coordinates | 1261087..1261344 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| VA249_RS24045 | 1256087..1256149 | + | 63 | Protein_1113 | DUF3265 domain-containing protein | - |
| VA249_RS05850 (VYA_10930) | 1256231..1256818 | + | 588 | WP_050917578.1 | hypothetical protein | - |
| VA249_RS05855 | 1256844..1256936 | + | 93 | WP_078555087.1 | DUF3265 domain-containing protein | - |
| VA249_RS05860 (VYA_10940) | 1256977..1257729 | + | 753 | WP_221069325.1 | class I SAM-dependent methyltransferase | - |
| VA249_RS05865 | 1258351..1258653 | - | 303 | WP_221069327.1 | hypothetical protein | - |
| VA249_RS05870 | 1258782..1258871 | + | 90 | WP_072829120.1 | DUF3265 domain-containing protein | - |
| VA249_RS24050 | 1259290..1259419 | + | 130 | Protein_1119 | DUF3265 domain-containing protein | - |
| VA249_RS05875 (VYA_10950) | 1259450..1259971 | + | 522 | WP_221069329.1 | GNAT family N-acetyltransferase | - |
| VA249_RS05880 (VYA_10960) | 1260092..1260514 | + | 423 | WP_221069331.1 | GNAT family N-acetyltransferase | - |
| VA249_RS05885 (VYA_10970) | 1261087..1261344 | + | 258 | WP_005448240.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| VA249_RS05890 (VYA_10980) | 1261332..1261634 | + | 303 | WP_221069333.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| VA249_RS05895 | 1261670..1261762 | + | 93 | WP_079758040.1 | DUF3265 domain-containing protein | - |
| VA249_RS05900 (VYA_10990) | 1261859..1262362 | + | 504 | WP_221069297.1 | hypothetical protein | - |
| VA249_RS05905 (VYA_11000) | 1262474..1263289 | + | 816 | WP_221069335.1 | DUF4393 domain-containing protein | - |
| VA249_RS05910 | 1263905..1263994 | + | 90 | WP_077345960.1 | DUF3265 domain-containing protein | - |
| VA249_RS05915 (VYA_11010) | 1264023..1264355 | + | 333 | WP_221069302.1 | 50S ribosome-binding protein YggL | - |
| VA249_RS05920 | 1264370..1264462 | + | 93 | WP_221069304.1 | DUF3265 domain-containing protein | - |
| VA249_RS05925 (VYA_11020) | 1264482..1265141 | - | 660 | WP_221069337.1 | DUF3800 domain-containing protein | - |
| VA249_RS05930 | 1265310..1265402 | + | 93 | WP_079758036.1 | DUF3265 domain-containing protein | - |
| VA249_RS05935 (VYA_11030) | 1265997..1266515 | + | 519 | WP_221069339.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1225667..1320873 | 95206 | |
| - | inside | Integron | - | - | 1226253..1318506 | 92253 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11651.55 Da Isoelectric Point: 4.8659
>T38062 WP_221069333.1 NZ_AP024165:1261332-1261634 [Vibrio alfacsensis]
MAEVIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEYLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLGKQ
MAEVIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEYLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLGKQ
Download Length: 303 bp
>T38062 NZ_AP024165:1261332-1261634 [Vibrio alfacsensis]
ATGGCTGAAGTAATCTGGACTGAACCAGCGTTATCTGACCTCAATGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTACAAACGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAGCTAGAATATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTCTGTTTGTTATGCGTGCAGAGAGAGATTTGCGTAAGTTCTTGTTGGGTAAGCAATAG
ATGGCTGAAGTAATCTGGACTGAACCAGCGTTATCTGACCTCAATGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTACAAACGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAGCTAGAATATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTCTGTTTGTTATGCGTGCAGAGAGAGATTTGCGTAAGTTCTTGTTGGGTAAGCAATAG
Antitoxin
Download Length: 86 a.a. Molecular weight: 9606.10 Da Isoelectric Point: 6.7269
>AT38062 WP_005448240.1 NZ_AP024165:1261087-1261344 [Vibrio alfacsensis]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK
Download Length: 258 bp
>AT38062 NZ_AP024165:1261087-1261344 [Vibrio alfacsensis]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACCAAAGAACCAGT
GTTAATTACTGAGCATGGTAAGCCATCTGCGTATCTAGTTGATGTTGATGACTACGAATTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCACTAGCTGATGGTAAAGTTGTAAGTCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAGTAA
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACCAAAGAACCAGT
GTTAATTACTGAGCATGGTAAGCCATCTGCGTATCTAGTTGATGTTGATGACTACGAATTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCACTAGCTGATGGTAAAGTTGTAAGTCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|