Detailed information of TA system TA038057

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-Phd
• Location: 234258..234919
• Replicon: chromosome
• Accession: NZ_AP024161
• Organism: Ralstonia solanacearum strain MAFF 311693

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JL096_RS00930
• Protein ID: WP_201016285.1
• Coordinates: 234506..234919 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q8Y121
• Locus tag: JL096_RS00925
• Protein ID: WP_011000825.1
• Coordinates: 234258..234509 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JL096_RS00915	229677..230072	-	396	WP_013211025.1	hypothetical protein	-
JL096_RS00920	230078..234178	-	4101	WP_201016284.1	tape measure protein	-
JL096_RS00925	234258..234509	+	252	WP_011000825.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JL096_RS00930	234506..234919	+	414	WP_201016285.1	type II toxin-antitoxin system VapC family toxin	Toxin
JL096_RS00935	234991..236013	-	1023	WP_201016286.1	DNA cytosine methyltransferase	-
JL096_RS00940	236637..236927	+	291	WP_016723655.1	H-NS histone family protein	-
JL096_RS00945	236970..237614	-	645	WP_201016287.1	hypothetical protein	-
JL096_RS00950	237589..237810	-	222	WP_201016288.1	hypothetical protein	-
JL096_RS00955	237807..238196	-	390	WP_201016289.1	hypothetical protein	-
JL096_RS00960	238205..238978	-	774	WP_201016290.1	hypothetical protein	-
JL096_RS00965	239079..239525	-	447	WP_111395520.1	hypothetical protein	-
JL096_RS00970	239531..239833	-	303	WP_201016291.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	215163..276115	60952

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-124)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-67)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15628.97 Da
• Isoelectric Point: 6.2337

>T38057 WP_201016285.1 NZ_AP024161:234506-234919 [Ralstonia solanacearum]
MSYLIDTNVLSELRRKAPDARVVAWMQDRPRQSLYLSVLTLGEIRKGIERLDDAIRRQHLIDWLEVELPNYFLGRLLDID
AHTADRWGRLMSSAGRPLPAIDGLLAATALQHDLTLVTRNTKDFAGLDVQLINPWEA

Nucleotide

• Length: 414 bp

>T38057 NZ_AP024161:234506-234919 [Ralstonia solanacearum]
TTGAGTTACCTGATCGACACCAATGTCCTGTCCGAATTGCGTCGCAAAGCGCCTGATGCGCGCGTGGTGGCCTGGATGCA
GGACCGCCCGCGCCAGTCGCTCTACCTGAGCGTGCTGACCCTGGGCGAGATTCGCAAAGGTATCGAGCGGCTGGACGACG
CGATACGCCGCCAGCACCTGATTGACTGGCTCGAAGTGGAACTGCCGAACTACTTTCTCGGCCGATTGCTCGACATCGAT
GCACATACTGCTGACCGCTGGGGCCGGCTGATGTCCTCGGCCGGCCGGCCGTTGCCCGCCATCGATGGCCTGCTGGCCGC
GACCGCCCTGCAACACGACCTCACGCTGGTCACGCGCAACACCAAGGATTTCGCGGGGCTCGACGTCCAGCTCATCAACC
CATGGGAAGCCTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9335.52 Da
• Isoelectric Point: 5.0774

>AT38057 WP_011000825.1 NZ_AP024161:234258-234509 [Ralstonia solanacearum]
MQSWQMQAAKARFSDVVKRAADDGPQEITVHGRPVAVVISRALFDRLSGSGESLVSFMRQSPLADQDDVVFERERSLPRE
VEF

Nucleotide

• Length: 252 bp

>AT38057 NZ_AP024161:234258-234509 [Ralstonia solanacearum]
ATGCAAAGCTGGCAAATGCAGGCCGCCAAGGCGCGGTTTTCCGATGTCGTGAAGCGGGCAGCAGACGACGGCCCGCAGGA
AATCACCGTGCATGGCCGCCCGGTGGCGGTAGTGATCTCGCGCGCACTGTTCGATCGCTTGAGCGGCAGCGGTGAGTCGC
TGGTCAGCTTCATGCGCCAATCCCCGCTGGCCGATCAGGACGATGTCGTTTTTGAGCGCGAGCGCAGCCTGCCGCGCGAG
GTCGAGTTTTGA

Structures

Antitoxin

• AlphaFold DB: Q8Y121