Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1964031..1964620 Replicon chromosome
Accession NZ_AP024159
Organism Ralstonia solanacearum strain MAFF 211479

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag JL097_RS09355 Protein ID WP_197342763.1
Coordinates 1964366..1964620 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JL097_RS09350 Protein ID WP_197368597.1
Coordinates 1964031..1964369 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL097_RS09320 1960277..1960615 + 339 WP_197368593.1 phage tail protein -
JL097_RS09325 1960612..1961247 + 636 WP_072633584.1 phage tail protein -
JL097_RS09330 1961253..1961849 + 597 WP_197368594.1 tail fiber assembly protein -
JL097_RS09335 1961846..1962547 + 702 WP_197368595.1 phage minor tail protein L -
JL097_RS09340 1962549..1963259 + 711 WP_197368596.1 C40 family peptidase -
JL097_RS09345 1963263..1963865 + 603 WP_087451243.1 tail assembly protein -
JL097_RS09350 1964031..1964369 - 339 WP_197368597.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JL097_RS09355 1964366..1964620 - 255 WP_197342763.1 type II toxin-antitoxin system HicA family toxin Toxin
JL097_RS09360 1964671..1967826 + 3156 WP_197368598.1 host specificity protein J -
JL097_RS09365 1967826..1968137 + 312 WP_071623779.1 hypothetical protein -
JL097_RS09370 1968163..1968819 + 657 WP_072633591.1 hypothetical protein -
JL097_RS09375 1968888..1969379 + 492 WP_011001641.1 glycoside hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1932183..1982684 50501


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9488.05 Da        Isoelectric Point: 10.3121

>T38053 WP_197342763.1 NZ_AP024159:c1964620-1964366 [Ralstonia solanacearum]
MKAKHQKTLELLFSRPTPAGIKWSDAVALMRELGAELEEREGSRVAVFLFGQVKVMHRPHPSPDMDKGAVASMRKWFEEN
GVKP

Download         Length: 255 bp

>T38053 NZ_AP024159:c1964620-1964366 [Ralstonia solanacearum]
ATGAAAGCCAAACACCAGAAGACGCTGGAGCTGCTCTTTTCCCGCCCTACGCCAGCGGGCATTAAGTGGTCTGATGCCGT
CGCGCTCATGCGAGAACTGGGCGCGGAATTGGAGGAGCGCGAGGGTTCTCGCGTGGCCGTCTTCCTGTTTGGTCAAGTTA
AAGTGATGCATCGACCGCACCCATCGCCTGATATGGACAAGGGCGCTGTGGCCTCGATGCGTAAGTGGTTCGAGGAAAAC
GGAGTCAAGCCATGA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12086.71 Da        Isoelectric Point: 5.1375

>AT38053 WP_197368597.1 NZ_AP024159:c1964369-1964031 [Ralstonia solanacearum]
MINVMNISGHKAVIAYDPDIEMFRGEFVGLNGGADFYAADVTGLHREGELSLRVFLEECTRRGVEPQKHFSGKFVLRVEG
KVHEAAAIAAAAQGVSLNQWAAGVLEQATEVA

Download         Length: 339 bp

>AT38053 NZ_AP024159:c1964369-1964031 [Ralstonia solanacearum]
ATGATCAACGTCATGAACATCAGCGGCCACAAGGCCGTCATCGCCTACGACCCGGATATCGAAATGTTCCGTGGCGAGTT
TGTTGGCCTGAACGGTGGCGCCGATTTCTACGCCGCCGATGTGACTGGCCTGCACCGCGAAGGTGAGTTGTCGCTGCGCG
TGTTTCTGGAAGAGTGCACACGGCGTGGCGTTGAGCCGCAAAAGCACTTTTCCGGCAAGTTCGTGCTGCGCGTGGAGGGC
AAGGTGCACGAGGCCGCCGCCATCGCCGCTGCCGCGCAAGGCGTGAGCCTTAACCAGTGGGCAGCCGGCGTGCTGGAGCA
AGCCACCGAGGTAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References