Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 958497..959152 Replicon chromosome
Accession NZ_AP024155
Organism Neisseria gonorrhoeae strain TUM 19855

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag JLZ01_RS04910 Protein ID WP_003691083.1
Coordinates 958497..958916 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag JLZ01_RS04915 Protein ID WP_003688410.1
Coordinates 958916..959152 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLZ01_RS04890 953731..955272 - 1542 WP_003701286.1 multidrug efflux MFS transporter -
JLZ01_RS04895 955420..956199 + 780 WP_003688416.1 (Fe-S)-binding protein -
JLZ01_RS04900 956196..956897 + 702 WP_003688414.1 lactate utilization protein C -
JLZ01_RS04905 956894..958348 + 1455 WP_003688412.1 iron-sulfur cluster-binding protein -
JLZ01_RS04910 958497..958916 - 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
JLZ01_RS04915 958916..959152 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
JLZ01_RS04920 959358..959555 - 198 WP_033910354.1 IS3 family transposase -
JLZ01_RS04925 959600..960178 - 579 WP_003688041.1 IS3 family transposase -
JLZ01_RS04930 960183..960611 - 429 WP_003701165.1 helix-turn-helix domain-containing protein -
JLZ01_RS04935 960823..961209 + 387 Protein_957 transposase -
JLZ01_RS04940 961592..962482 - 891 WP_002244992.1 succinate--CoA ligase subunit alpha -
JLZ01_RS04945 962493..963659 - 1167 WP_003688408.1 ADP-forming succinate--CoA ligase subunit beta -
JLZ01_RS04950 963731..964018 - 288 WP_003688407.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T38047 WP_003691083.1 NZ_AP024155:c958916-958497 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

>T38047 NZ_AP024155:c958916-958497 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT38047 WP_003688410.1 NZ_AP024155:c959152-958916 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp

>AT38047 NZ_AP024155:c959152-958916 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References