Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5804680..5805330 Replicon chromosome
Accession NZ_AP024145
Organism Methylobacterium indicum strain VL1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag miv_RS26970 Protein ID WP_207179951.1
Coordinates 5805121..5805330 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID -
Locus tag miv_RS26965 Protein ID WP_207179950.1
Coordinates 5804680..5805084 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
miv_RS26950 5800990..5802273 + 1284 WP_207179947.1 hydroxymethylglutaryl-CoA reductase, degradative -
miv_RS26955 5802536..5803756 + 1221 WP_207179948.1 ABC transporter substrate-binding protein -
miv_RS26960 5803753..5804646 + 894 WP_207179949.1 hydroxymethylglutaryl-CoA lyase -
miv_RS26965 5804680..5805084 - 405 WP_207179950.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
miv_RS26970 5805121..5805330 - 210 WP_207179951.1 type II toxin-antitoxin system HicA family toxin Toxin
miv_RS26975 5805554..5807164 - 1611 WP_207179952.1 galactarate dehydratase -
miv_RS26980 5807356..5808303 - 948 WP_048429362.1 agmatinase -
miv_RS26985 5808487..5809287 - 801 WP_207179953.1 amino acid ABC transporter ATP-binding protein -
miv_RS26990 5809284..5809889 - 606 WP_207183645.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(11-67)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(7-126)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7756.90 Da        Isoelectric Point: 10.7459

>T38046 WP_207179951.1 NZ_AP024145:c5805330-5805121 [Methylobacterium indicum]
MAPKQRSRKTRDVLAMLVKDGWFVARKGPGDHVQYKHPTKPGKVTVDGGASEIPTGTLHNIYRQAGWEW

Download         Length: 210 bp

>T38046 NZ_AP024145:c5805330-5805121 [Methylobacterium indicum]
ATGGCTCCTAAACAGAGAAGCCGCAAAACCCGTGACGTGCTCGCGATGCTCGTGAAGGACGGATGGTTCGTCGCCCGCAA
GGGTCCCGGTGATCACGTCCAGTACAAGCACCCGACCAAGCCCGGAAAGGTTACGGTCGATGGCGGGGCGTCCGAGATCC
CGACCGGGACGCTTCATAACATCTACCGGCAAGCGGGATGGGAGTGGTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14313.20 Da        Isoelectric Point: 4.4323

>AT38046 WP_207179950.1 NZ_AP024145:c5805084-5804680 [Methylobacterium indicum]
MVRIVMLVHEEEGVFGASFPDFPGATTVADDLDTLYRKAAEMLAFHVNGMAEDGDAIPALRTLSELQQDPVFRDDSEGAM
IGLVDVDLPGKAVRVNVSIEESLLKRIDHAAAAAGESRSSFLARAARARLSTAA

Download         Length: 405 bp

>AT38046 NZ_AP024145:c5805084-5804680 [Methylobacterium indicum]
ATGGTCCGCATCGTCATGCTGGTTCACGAAGAAGAGGGAGTCTTCGGCGCCTCATTCCCGGATTTTCCAGGTGCAACGAC
CGTCGCCGACGATCTCGACACGCTCTATCGCAAGGCGGCCGAGATGCTCGCCTTCCACGTCAACGGCATGGCCGAGGACG
GAGACGCCATTCCGGCCCTGCGCACCCTGAGCGAGTTGCAGCAGGATCCGGTGTTCCGGGACGACAGCGAGGGCGCCATG
ATCGGTCTCGTCGACGTCGATCTGCCCGGCAAGGCGGTGCGGGTGAACGTCTCCATCGAGGAGAGCCTCCTCAAGCGGAT
CGACCACGCCGCCGCCGCCGCCGGCGAGAGCCGGTCGAGCTTCCTCGCCCGGGCGGCCCGGGCTCGCCTATCGACAGCCG
CCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References