Detailed information of TA system TA038045

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 3967475..3968011
• Replicon: chromosome
• Accession: NZ_AP024145
• Organism: Methylobacterium indicum strain VL1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A0J6R5N2
• Locus tag: miv_RS18480
• Protein ID: WP_048427813.1
• Coordinates: 3967475..3967765 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: miv_RS18485
• Protein ID: WP_082711384.1
• Coordinates: 3967766..3968011 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
miv_RS18465	3964200..3965147	-	948	WP_207183546.1	glycosyltransferase family 2 protein	-
miv_RS18470	3965162..3966064	-	903	WP_207183547.1	rhamnosyltransferase	-
miv_RS18475	3966373..3967437	+	1065	WP_207178141.1	DUF1612 domain-containing protein	-
miv_RS18480	3967475..3967765	-	291	WP_048427813.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
miv_RS18485	3967766..3968011	-	246	WP_082711384.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
miv_RS18490	3968185..3968994	+	810	WP_058620123.1	DeoR/GlpR family DNA-binding transcription regulator	-
miv_RS18495	3969102..3970700	+	1599	WP_207178143.1	glycerol-3-phosphate dehydrogenase	-
miv_RS18500	3970727..3971824	+	1098	WP_207178145.1	ABC transporter ATP-binding protein	-
miv_RS18505	3971841..3972926	+	1086	WP_207178147.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-92)

Antitoxin

• Antitoxin ParD (4-72)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11023.55 Da
• Isoelectric Point: 10.6564

>T38045 WP_048427813.1 NZ_AP024145:c3967765-3967475 [Methylobacterium indicum]
VRIRLSAAARRDLSGIWSYSAEKWDRAQADRYIRVIADGFDRLAAGTAKSRSADDIRRGYFKLVVGSHVVFYRKGASDVI
EVVRILHQQMDFDRHL

Nucleotide

• Length: 291 bp

>T38045 NZ_AP024145:c3967765-3967475 [Methylobacterium indicum]
GTGCGTATCCGGCTCTCAGCCGCCGCTCGCCGTGACCTGTCTGGCATTTGGTCCTACTCGGCCGAAAAGTGGGACAGGGC
ACAGGCTGACCGATATATTCGGGTGATCGCGGATGGCTTCGATCGCCTTGCCGCCGGCACCGCGAAAAGCCGTAGCGCCG
ATGACATCAGGCGCGGCTACTTCAAACTCGTGGTCGGTTCACATGTCGTCTTCTACCGAAAAGGCGCCAGTGACGTCATC
GAGGTCGTCCGCATCCTGCACCAGCAGATGGACTTTGATCGCCACCTGTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9194.07 Da
• Isoelectric Point: 4.5084

>AT38045 WP_082711384.1 NZ_AP024145:c3968011-3967766 [Methylobacterium indicum]
MARNTSVSLGEHFTQFIDRQVDGGRYNSASDVVRAGLRLLEEREAKLDALRSALIEGEASSEFQDFDTEHFLKSMRQSDE
Q

Nucleotide

• Length: 246 bp

>AT38045 NZ_AP024145:c3968011-3967766 [Methylobacterium indicum]
ATGGCCCGCAACACGTCGGTTTCGCTCGGCGAGCACTTCACTCAATTCATCGATCGGCAAGTCGACGGCGGTCGATACAA
CTCAGCCAGCGATGTGGTTCGCGCTGGATTACGCCTGCTTGAAGAGCGAGAAGCAAAGCTTGATGCGTTGCGATCAGCTC
TGATCGAGGGAGAAGCCAGTAGTGAGTTCCAGGATTTCGACACCGAACATTTTCTGAAATCCATGCGTCAGTCGGACGAG
CAGTAG

Structures

Toxin

• AlphaFold DB: A0A0J6R5N2