Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3867650..3868485 Replicon chromosome
Accession NZ_AP024130
Organism Escherichia coli strain SI-NP020

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag FFK26_RS18730 Protein ID WP_000854828.1
Coordinates 3867650..3868027 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag FFK26_RS18735 Protein ID WP_001285572.1
Coordinates 3868117..3868485 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FFK26_RS18700 (3862908) 3862908..3863864 + 957 WP_137564198.1 molybdenum cofactor insertion chaperone PaoD -
FFK26_RS18705 (3863915) 3863915..3864253 + 339 Protein_3673 LysR substrate-binding domain-containing protein -
FFK26_RS18710 (3864591) 3864591..3865910 + 1320 WP_000144688.1 site-specific integrase -
FFK26_RS18715 (3866003) 3866003..3866851 - 849 WP_000014502.1 DUF4942 domain-containing protein -
FFK26_RS18720 (3866948) 3866948..3867145 - 198 WP_000772024.1 DUF957 domain-containing protein -
FFK26_RS18725 (3867165) 3867165..3867653 - 489 WP_000761700.1 DUF5983 family protein -
FFK26_RS18730 (3867650) 3867650..3868027 - 378 WP_000854828.1 TA system toxin CbtA family protein Toxin
FFK26_RS18735 (3868117) 3868117..3868485 - 369 WP_001285572.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
FFK26_RS18740 (3868535) 3868535..3869182 - 648 WP_000094921.1 hypothetical protein -
FFK26_RS18745 (3869201) 3869201..3869422 - 222 WP_000692303.1 DUF987 domain-containing protein -
FFK26_RS18750 (3869491) 3869491..3869967 - 477 WP_001186724.1 RadC family protein -
FFK26_RS18755 (3869983) 3869983..3870465 - 483 WP_000213707.1 antirestriction protein -
FFK26_RS18760 (3870554) 3870554..3871372 - 819 WP_001234691.1 DUF932 domain-containing protein -
FFK26_RS18765 (3871472) 3871472..3871705 - 234 WP_024210659.1 DUF905 family protein -
FFK26_RS18770 (3871784) 3871784..3872239 - 456 WP_000581504.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE 3837414..3889597 52183


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13998.08 Da        Isoelectric Point: 9.9962

>T38034 WP_000854828.1 NZ_AP024130:c3868027-3867650 [Escherichia coli]
MKTLPVLPGQSASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVKFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITRGKHPEAKR

Download         Length: 378 bp

>T38034 NZ_AP024130:c3868027-3867650 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGTCGGCCAGTTCACGCCCATCTCCTGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAAATTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCGGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13602.41 Da        Isoelectric Point: 6.7386

>AT38034 WP_001285572.1 NZ_AP024130:c3868485-3868117 [Escherichia coli]
VSDTLPGTTHPDDNHDRPWWGLPCTATPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT38034 NZ_AP024130:c3868485-3868117 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTACCCTGCACCGCGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References