Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3671444..3672062 Replicon chromosome
Accession NZ_AP024130
Organism Escherichia coli strain SI-NP020

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag FFK26_RS17820 Protein ID WP_001291435.1
Coordinates 3671844..3672062 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag FFK26_RS17815 Protein ID WP_000344800.1
Coordinates 3671444..3671818 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FFK26_RS17805 (3666533) 3666533..3667726 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
FFK26_RS17810 (3667749) 3667749..3670898 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
FFK26_RS17815 (3671444) 3671444..3671818 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
FFK26_RS17820 (3671844) 3671844..3672062 + 219 WP_001291435.1 HHA domain-containing protein Toxin
FFK26_RS17825 (3672233) 3672233..3672784 + 552 WP_000102564.1 maltose O-acetyltransferase -
FFK26_RS17830 (3672900) 3672900..3673370 + 471 WP_000136192.1 YlaC family protein -
FFK26_RS17835 (3673534) 3673534..3675084 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
FFK26_RS17840 (3675126) 3675126..3675479 - 354 WP_000878140.1 DUF1428 domain-containing protein -
FFK26_RS17850 (3675858) 3675858..3676169 + 312 WP_000409911.1 MGMT family protein -
FFK26_RS17855 (3676200) 3676200..3676772 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T38032 WP_001291435.1 NZ_AP024130:3671844-3672062 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T38032 NZ_AP024130:3671844-3672062 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT38032 WP_000344800.1 NZ_AP024130:3671444-3671818 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT38032 NZ_AP024130:3671444-3671818 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References