Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2947434..2948269 Replicon chromosome
Accession NZ_AP024130
Organism Escherichia coli strain SI-NP020

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag FFK26_RS14555 Protein ID WP_137564503.1
Coordinates 2947434..2947811 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag FFK26_RS14560 Protein ID WP_137564504.1
Coordinates 2947901..2948269 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FFK26_RS14515 (2942435) 2942435..2942926 - 492 WP_001297187.1 DUF1097 domain-containing protein -
FFK26_RS14520 (2943028) 2943028..2943582 - 555 WP_001001902.1 molecular chaperone YcdY -
FFK26_RS14525 (2943606) 2943606..2944343 - 738 WP_000283664.1 zinc-binding phosphatase -
FFK26_RS14530 (2944398) 2944398..2945336 - 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
FFK26_RS14540 (2945807) 2945807..2946649 - 843 WP_137564507.1 DUF4942 domain-containing protein -
FFK26_RS14545 (2946734) 2946734..2946931 - 198 WP_032256361.1 DUF957 domain-containing protein -
FFK26_RS14550 (2946949) 2946949..2947437 - 489 WP_137564502.1 DUF5983 family protein -
FFK26_RS14555 (2947434) 2947434..2947811 - 378 WP_137564503.1 TA system toxin CbtA family protein Toxin
FFK26_RS14560 (2947901) 2947901..2948269 - 369 WP_137564504.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FFK26_RS14565 (2948349) 2948349..2948570 - 222 WP_000692347.1 DUF987 domain-containing protein -
FFK26_RS14570 (2948657) 2948657..2949133 - 477 WP_001186774.1 RadC family protein -
FFK26_RS14575 (2949149) 2949149..2949634 - 486 WP_137564505.1 antirestriction protein -
FFK26_RS14580 (2949689) 2949689..2950507 - 819 WP_072855048.1 DUF932 domain-containing protein -
FFK26_RS14585 (2950607) 2950607..2950840 - 234 WP_001119729.1 DUF905 family protein -
FFK26_RS14590 (2950919) 2950919..2951374 - 456 WP_000581504.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14087.15 Da        Isoelectric Point: 8.2904

>T38031 WP_137564503.1 NZ_AP024130:c2947811-2947434 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLILNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMVRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T38031 NZ_AP024130:c2947811-2947434 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGGTTGCTGGACCAGCATTACGGCCTCATACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGTCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13617.46 Da        Isoelectric Point: 6.4669

>AT38031 WP_137564504.1 NZ_AP024130:c2948269-2947901 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVKLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT38031 NZ_AP024130:c2948269-2947901 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCAAGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References