Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2497802..2498440 Replicon chromosome
Accession NZ_AP024130
Organism Escherichia coli strain SI-NP020

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag FFK26_RS12170 Protein ID WP_000813794.1
Coordinates 2498264..2498440 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FFK26_RS12165 Protein ID WP_001270286.1
Coordinates 2497802..2498218 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FFK26_RS12145 (2492954) 2492954..2493895 - 942 WP_001251313.1 ABC transporter permease -
FFK26_RS12150 (2493896) 2493896..2494909 - 1014 WP_000220399.1 ABC transporter ATP-binding protein -
FFK26_RS12155 (2494927) 2494927..2496072 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
FFK26_RS12160 (2496317) 2496317..2497723 - 1407 WP_000760663.1 PLP-dependent aminotransferase family protein -
FFK26_RS12165 (2497802) 2497802..2498218 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
FFK26_RS12170 (2498264) 2498264..2498440 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
FFK26_RS12175 (2498662) 2498662..2498892 + 231 WP_000494244.1 YncJ family protein -
FFK26_RS12180 (2498984) 2498984..2500945 - 1962 WP_001442195.1 23S rRNA 5-hydroxycytidine C2501 synthase -
FFK26_RS12185 (2501018) 2501018..2501554 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
FFK26_RS12190 (2501646) 2501646..2502821 + 1176 WP_231257325.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T38029 WP_000813794.1 NZ_AP024130:c2498440-2498264 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T38029 NZ_AP024130:c2498440-2498264 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT38029 WP_001270286.1 NZ_AP024130:c2498218-2497802 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT38029 NZ_AP024130:c2498218-2497802 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAATTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTTGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References