Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1401583..1402208 Replicon chromosome
Accession NZ_AP024130
Organism Escherichia coli strain SI-NP020

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FFK26_RS06890 Protein ID WP_000911330.1
Coordinates 1401810..1402208 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag FFK26_RS06885 Protein ID WP_000450524.1
Coordinates 1401583..1401810 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FFK26_RS06860 (1397386) 1397386..1397856 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
FFK26_RS06865 (1397856) 1397856..1398428 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
FFK26_RS06870 (1398574) 1398574..1399452 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
FFK26_RS06875 (1399469) 1399469..1400503 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
FFK26_RS06880 (1400716) 1400716..1401429 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
FFK26_RS06885 (1401583) 1401583..1401810 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
FFK26_RS06890 (1401810) 1401810..1402208 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
FFK26_RS06895 (1402355) 1402355..1403218 + 864 WP_001267508.1 neutral zinc metallopeptidase -
FFK26_RS06900 (1403233) 1403233..1405248 + 2016 WP_000829335.1 tRNA cytosine(34) acetyltransferase TmcA -
FFK26_RS06905 (1405322) 1405322..1406020 + 699 WP_000679812.1 esterase -
FFK26_RS06910 (1406101) 1406101..1406301 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T38018 WP_000911330.1 NZ_AP024130:1401810-1402208 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T38018 NZ_AP024130:1401810-1402208 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT38018 WP_000450524.1 NZ_AP024130:1401583-1401810 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT38018 NZ_AP024130:1401583-1401810 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References