Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsxAB/Xre(antitoxin) |
| Location | 7210..7711 | Replicon | plasmid NS-NP030_P2 |
| Accession | NZ_AP024128 | ||
| Organism | Escherichia coli strain NS-NP030 | ||
Toxin (Protein)
| Gene name | TsxA | Uniprot ID | H1ZXU8 |
| Locus tag | FFJ14_RS26445 | Protein ID | WP_000702247.1 |
| Coordinates | 7210..7470 (+) | Length | 87 a.a. |
Antitoxin (Protein)
| Gene name | TsxB | Uniprot ID | - |
| Locus tag | FFJ14_RS26450 | Protein ID | WP_001132407.1 |
| Coordinates | 7460..7711 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FFJ14_RS27135 (BvCmsNSNP030_5202) | 2376..2528 | + | 153 | Protein_3 | FlmC family protein | - |
| FFJ14_RS26400 (BvCmsNSNP030_5202) | 2476..2595 | + | 120 | WP_227525580.1 | Hok/Gef family protein | - |
| FFJ14_RS26405 (BvCmsNSNP030_5203) | 2745..3341 | + | 597 | WP_000125164.1 | ProQ/FINO family protein | - |
| FFJ14_RS26410 (BvCmsNSNP030_5204) | 3359..3643 | - | 285 | WP_001162371.1 | hypothetical protein | - |
| FFJ14_RS26415 (BvCmsNSNP030_5205) | 3717..4382 | - | 666 | WP_000532148.1 | division plane positioning ATPase MipZ | - |
| FFJ14_RS26420 (BvCmsNSNP030_5206) | 4979..5308 | + | 330 | WP_000855119.1 | hypothetical protein | - |
| FFJ14_RS26425 (BvCmsNSNP030_5207) | 5359..5733 | + | 375 | WP_137544955.1 | phage tail protein | - |
| FFJ14_RS26430 (BvCmsNSNP030_5208) | 6263..6586 | + | 324 | WP_000427403.1 | hypothetical protein | - |
| FFJ14_RS26435 (BvCmsNSNP030_5209) | 6628..6837 | + | 210 | WP_000866036.1 | hypothetical protein | - |
| FFJ14_RS26440 (BvCmsNSNP030_5210) | 6934..7158 | + | 225 | WP_000814381.1 | hypothetical protein | - |
| FFJ14_RS26445 (BvCmsNSNP030_5211) | 7210..7470 | + | 261 | WP_000702247.1 | hypothetical protein | Toxin |
| FFJ14_RS26450 (BvCmsNSNP030_5212) | 7460..7711 | + | 252 | WP_001132407.1 | transcriptional regulator | Antitoxin |
| FFJ14_RS26455 (BvCmsNSNP030_5213) | 8261..8539 | + | 279 | WP_000545938.1 | hypothetical protein | - |
| FFJ14_RS27140 (BvCmsNSNP030_5215) | 8927..9370 | - | 444 | WP_000192626.1 | hypothetical protein | - |
| FFJ14_RS26465 (BvCmsNSNP030_5216) | 9667..9849 | + | 183 | WP_000833470.1 | type II toxin-antitoxin system HicA family toxin | - |
| FFJ14_RS26470 (BvCmsNSNP030_5217) | 9874..10311 | + | 438 | WP_000466318.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| FFJ14_RS26475 (BvCmsNSNP030_5218) | 10442..10762 | - | 321 | WP_000206710.1 | hypothetical protein | - |
| FFJ14_RS26480 (BvCmsNSNP030_5219) | 10773..11036 | - | 264 | WP_000224227.1 | hypothetical protein | - |
| FFJ14_RS26485 (BvCmsNSNP030_5220) | 11038..11529 | - | 492 | WP_001167293.1 | hypothetical protein | - |
| FFJ14_RS27145 | 11838..11978 | - | 141 | Protein_22 | hypothetical protein | - |
| FFJ14_RS26495 (BvCmsNSNP030_5222) | 11998..12705 | - | 708 | WP_000108795.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | - | 1..58397 | 58397 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 87 a.a. Molecular weight: 9817.29 Da Isoelectric Point: 10.0665
>T38013 WP_000702247.1 NZ_AP024128:7210-7470 [Escherichia coli]
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEKAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEKAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
Download Length: 261 bp
>T38013 NZ_AP024128:7210-7470 [Escherichia coli]
ATGAAGATAAGAAAAGGTGACAGACAATATTATCTGAATAAAGAAGGTGATACGTTTCATCTGGTGAAGCGAGTAAAAAC
TTTTTCTAAGTCTGCGACTTTAGGAAAAACGAAAGCAACGGTGAAAACTGTTGCCGATCTTGTTTTTCATGAGAAGGCAT
TCGACACTATCGACTTTGCCAGCGACGGATTAAGAGAGAATGATAAAGAAATTGTTTCTATGATGATTCAGGAAATGAGT
GAGGGAAAAAATGCCAAATGA
ATGAAGATAAGAAAAGGTGACAGACAATATTATCTGAATAAAGAAGGTGATACGTTTCATCTGGTGAAGCGAGTAAAAAC
TTTTTCTAAGTCTGCGACTTTAGGAAAAACGAAAGCAACGGTGAAAACTGTTGCCGATCTTGTTTTTCATGAGAAGGCAT
TCGACACTATCGACTTTGCCAGCGACGGATTAAGAGAGAATGATAAAGAAATTGTTTCTATGATGATTCAGGAAATGAGT
GAGGGAAAAAATGCCAAATGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9404.77 Da Isoelectric Point: 9.8120
>AT38013 WP_001132407.1 NZ_AP024128:7460-7711 [Escherichia coli]
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
Download Length: 252 bp
>AT38013 NZ_AP024128:7460-7711 [Escherichia coli]
ATGCCAAATGAAAACACACCAGAAAACATTAAACGTCTGCGGCAAAAAATTGGCCTGACACAGAAAGAATGTGCCGAAAT
ATTTAGCATGAGTCCGCGTACCTGGCGTCGCAAAGAAGAACCTGTCGGAACTGCAAGCGGTACAGCACTTACACCAGTAG
AGTTTAAATTTCTTCTGCTTTTAGCTGGAGAACACCCTGATTATGTACTTTGTAAAAGGAATAAAAAGAATTCTGATTCT
GGAAGTAATTAA
ATGCCAAATGAAAACACACCAGAAAACATTAAACGTCTGCGGCAAAAAATTGGCCTGACACAGAAAGAATGTGCCGAAAT
ATTTAGCATGAGTCCGCGTACCTGGCGTCGCAAAGAAGAACCTGTCGGAACTGCAAGCGGTACAGCACTTACACCAGTAG
AGTTTAAATTTCTTCTGCTTTTAGCTGGAGAACACCCTGATTATGTACTTTGTAAAAGGAATAAAAAGAATTCTGATTCT
GGAAGTAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|