Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4764792..4765423 Replicon chromosome
Accession NZ_AP024126
Organism Escherichia coli strain NS-NP030

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag FFJ14_RS23265 Protein ID WP_001259385.1
Coordinates 4765148..4765423 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q31VE4
Locus tag FFJ14_RS23260 Protein ID WP_000593554.1
Coordinates 4764792..4765151 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FFJ14_RS23230 (4759904) 4759904..4760377 + 474 WP_001161553.1 PTS sugar transporter subunit IIA -
FFJ14_RS23235 (4760374) 4760374..4760655 + 282 WP_000084022.1 PTS sugar transporter subunit IIB -
FFJ14_RS23240 (4760732) 4760732..4762090 + 1359 WP_137545010.1 PTS galactitol transporter subunit IIC -
FFJ14_RS23245 (4762083) 4762083..4763591 + 1509 WP_001298718.1 FGGY-family carbohydrate kinase -
FFJ14_RS23250 (4763581) 4763581..4763850 + 270 WP_000933060.1 HPr family phosphocarrier protein -
FFJ14_RS23255 (4763882) 4763882..4764742 + 861 WP_001131783.1 class II aldolase -
FFJ14_RS23260 (4764792) 4764792..4765151 - 360 WP_000593554.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FFJ14_RS23265 (4765148) 4765148..4765423 - 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
FFJ14_RS23270 (4765496) 4765496..4766620 - 1125 WP_001216257.1 ABC transporter permease -
FFJ14_RS23275 (4766620) 4766620..4769355 - 2736 WP_000149167.1 ribosome-associated ATPase/putative transporter RbbA -
FFJ14_RS23280 (4769352) 4769352..4770377 - 1026 WP_137545009.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T38004 WP_001259385.1 NZ_AP024126:c4765423-4765148 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T38004 NZ_AP024126:c4765423-4765148 [Escherichia coli]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13359.25 Da        Isoelectric Point: 4.8838

>AT38004 WP_000593554.1 NZ_AP024126:c4765151-4764792 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLLEYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT38004 NZ_AP024126:c4765151-4764792 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCAGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCTAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A6H2GM94

References