Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2978650..2979121 Replicon chromosome
Accession NZ_AP024126
Organism Escherichia coli strain NS-NP030

Toxin (Protein)


Gene name parE_1 Uniprot ID -
Locus tag FFJ14_RS14740 Protein ID WP_097430266.1
Coordinates 2978843..2979121 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag FFJ14_RS14735 Protein ID WP_001302048.1
Coordinates 2978650..2978841 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FFJ14_RS14695 (2973887) 2973887..2974042 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
FFJ14_RS14700 (2974280) 2974280..2974945 - 666 WP_021554705.1 epoxyqueuosine reductase QueH -
FFJ14_RS14705 (2975130) 2975130..2975546 - 417 WP_097430262.1 DUF977 family protein -
FFJ14_RS14710 (2975587) 2975587..2976696 - 1110 WP_097430263.1 DNA-binding protein -
FFJ14_RS14715 (2976775) 2976775..2977230 + 456 WP_097430264.1 hypothetical protein -
FFJ14_RS14720 (2977437) 2977437..2977862 - 426 WP_097430265.1 toxin YdaT family protein -
FFJ14_RS14725 (2977859) 2977859..2978161 - 303 WP_000172735.1 transcriptional regulator -
FFJ14_RS14730 (2978258) 2978258..2978629 + 372 WP_123005401.1 hypothetical protein -
FFJ14_RS14735 (2978650) 2978650..2978841 + 192 WP_001302048.1 hypothetical protein Antitoxin
FFJ14_RS14740 (2978843) 2978843..2979121 + 279 WP_097430266.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FFJ14_RS14745 (2979410) 2979410..2979541 + 132 WP_097430272.1 DUF1391 family protein -
FFJ14_RS27015 (2979567) 2979567..2979695 + 129 WP_000344964.1 protein YdfB -
FFJ14_RS14750 (2979725) 2979725..2979943 + 219 WP_001171942.1 protein YdfC -
FFJ14_RS14755 (2980511) 2980511..2980699 + 189 WP_000854558.1 cell division inhibition protein DicB -
FFJ14_RS14760 (2980696) 2980696..2980887 + 192 WP_097430267.1 DUF1482 family protein -
FFJ14_RS27020 (2981122) 2981122..2981487 + 366 Protein_2901 exonuclease -
FFJ14_RS27025 (2982898) 2982898..2983422 + 525 WP_244584446.1 3'-5' exonuclease -
FFJ14_RS14770 (2983481) 2983481..2983684 + 204 WP_000096344.1 DUF4224 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10660.26 Da        Isoelectric Point: 6.2092

>T37998 WP_097430266.1 NZ_AP024126:2978843-2979121 [Escherichia coli]
MLPVLWLESADTNLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

>T37998 NZ_AP024126:2978843-2979121 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCAACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT37998 WP_001302048.1 NZ_AP024126:2978650-2978841 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp

>AT37998 NZ_AP024126:2978650-2978841 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAAATGCGCAAGGAACGGAGCAAGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References