Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1322372..1322843 Replicon chromosome
Accession NZ_AP024123
Organism Escherichia coli strain KS-NP019

Toxin (Protein)


Gene name parE_1 Uniprot ID -
Locus tag FFG67_RS06645 Protein ID WP_097430266.1
Coordinates 1322565..1322843 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag FFG67_RS06640 Protein ID WP_001302048.1
Coordinates 1322372..1322563 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FFG67_RS06600 (1317609) 1317609..1317764 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
FFG67_RS06605 (1318002) 1318002..1318667 - 666 WP_021554705.1 epoxyqueuosine reductase QueH -
FFG67_RS06610 (1318852) 1318852..1319268 - 417 WP_097430262.1 DUF977 family protein -
FFG67_RS06615 (1319309) 1319309..1320418 - 1110 WP_220571790.1 DNA-binding protein -
FFG67_RS06620 (1320497) 1320497..1320952 + 456 WP_220571784.1 hypothetical protein -
FFG67_RS06625 (1321159) 1321159..1321584 - 426 WP_097430265.1 toxin YdaT family protein -
FFG67_RS06630 (1321581) 1321581..1321883 - 303 WP_000172735.1 transcriptional regulator -
FFG67_RS06635 (1321980) 1321980..1322351 + 372 WP_123005401.1 hypothetical protein -
FFG67_RS06640 (1322372) 1322372..1322563 + 192 WP_001302048.1 hypothetical protein Antitoxin
FFG67_RS06645 (1322565) 1322565..1322843 + 279 WP_097430266.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FFG67_RS06650 (1323132) 1323132..1323263 + 132 WP_097430272.1 DUF1391 family protein -
FFG67_RS26405 (1323289) 1323289..1323417 + 129 WP_000344964.1 protein YdfB -
FFG67_RS06655 (1323447) 1323447..1323665 + 219 WP_001171942.1 protein YdfC -
FFG67_RS06660 (1324233) 1324233..1324421 + 189 WP_000854558.1 cell division inhibition protein DicB -
FFG67_RS06665 (1324418) 1324418..1324609 + 192 WP_097430267.1 DUF1482 family protein -
FFG67_RS26410 (1324844) 1324844..1325209 + 366 Protein_1318 exonuclease -
FFG67_RS26415 (1326620) 1326620..1327144 + 525 WP_244584446.1 3'-5' exonuclease -
FFG67_RS06675 (1327203) 1327203..1327406 + 204 WP_000096344.1 DUF4224 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10660.26 Da        Isoelectric Point: 6.2092

>T37953 WP_097430266.1 NZ_AP024123:1322565-1322843 [Escherichia coli]
MLPVLWLESADTNLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

>T37953 NZ_AP024123:1322565-1322843 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCAACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT37953 WP_001302048.1 NZ_AP024123:1322372-1322563 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp

>AT37953 NZ_AP024123:1322372-1322563 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAAATGCGCAAGGAACGGAGCAAGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References