Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4502819..4503617 Replicon chromosome
Accession NZ_AP024114
Organism Escherichia coli strain JML285

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag FFF71_RS21675 Protein ID WP_000854735.1
Coordinates 4503240..4503617 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A067H947
Locus tag FFF71_RS21670 Protein ID WP_001285415.1
Coordinates 4502819..4503193 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FFF71_RS21635 (4498750) 4498750..4499430 + 681 WP_001282919.1 WYL domain-containing protein -
FFF71_RS21640 (4499578) 4499578..4500255 + 678 WP_001097301.1 hypothetical protein -
FFF71_RS21645 (4500261) 4500261..4500494 + 234 WP_001278287.1 DUF905 family protein -
FFF71_RS21650 (4500584) 4500584..4501402 + 819 WP_001175148.1 DUF932 domain-containing protein -
FFF71_RS21655 (4501484) 4501484..4501963 + 480 WP_000844100.1 antirestriction protein -
FFF71_RS21660 (4501979) 4501979..4502455 + 477 WP_001366855.1 RadC family protein -
FFF71_RS21665 (4502518) 4502518..4502739 + 222 WP_000692309.1 DUF987 domain-containing protein -
FFF71_RS21670 (4502819) 4502819..4503193 + 375 WP_001285415.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FFF71_RS21675 (4503240) 4503240..4503617 + 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
FFF71_RS21680 (4503614) 4503614..4504102 + 489 WP_000761676.1 DUF5983 family protein -
FFF71_RS21685 (4504114) 4504114..4504311 + 198 WP_000839291.1 DUF957 domain-containing protein -
FFF71_RS21690 (4504396) 4504396..4505262 + 867 WP_001280433.1 DUF4942 domain-containing protein -
FFF71_RS21695 (4505334) 4505334..4505597 + 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
FFF71_RS21700 (4505594) 4505594..4505920 + 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
FFF71_RS21705 (4506803) 4506803..4508341 + 1539 WP_001187182.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4482372..4516154 33782


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T37924 WP_000854735.1 NZ_AP024114:4503240-4503617 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T37924 NZ_AP024114:4503240-4503617 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13663.32 Da        Isoelectric Point: 5.8640

>AT37924 WP_001285415.1 NZ_AP024114:4502819-4503193 [Escherichia coli]
VSDTHPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT37924 NZ_AP024114:4502819-4503193 [Escherichia coli]
GTGTCAGACACACACCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGGGGGCAGT
TTAGCGACGCGGATGCGTATCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A067H947

References