Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 784507..785342 | Replicon | chromosome |
| Accession | NZ_AP024114 | ||
| Organism | Escherichia coli strain JML285 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | F2VI91 |
| Locus tag | FFF71_RS03825 | Protein ID | WP_000854748.1 |
| Coordinates | 784507..784884 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | FFF71_RS03830 | Protein ID | WP_040089920.1 |
| Coordinates | 784974..785342 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FFF71_RS03790 (779574) | 779574..780179 | + | 606 | WP_001255030.1 | type II secretion system minor pseudopilin GspJ | - |
| FFF71_RS03795 (780176) | 780176..781153 | + | 978 | WP_000633209.1 | type II secretion system minor pseudopilin GspK | - |
| FFF71_RS03800 (781150) | 781150..782328 | + | 1179 | WP_000094972.1 | type II secretion system protein GspL | - |
| FFF71_RS03805 (782330) | 782330..782866 | + | 537 | WP_000942770.1 | GspM family type II secretion system protein YghD | - |
| FFF71_RS03810 (783147) | 783147..783716 | - | 570 | WP_001290247.1 | DUF4942 domain-containing protein | - |
| FFF71_RS03815 (783813) | 783813..784010 | - | 198 | WP_000839281.1 | DUF957 domain-containing protein | - |
| FFF71_RS03820 (784022) | 784022..784510 | - | 489 | WP_053900379.1 | DUF5983 family protein | - |
| FFF71_RS03825 (784507) | 784507..784884 | - | 378 | WP_000854748.1 | TA system toxin CbtA family protein | Toxin |
| FFF71_RS03830 (784974) | 784974..785342 | - | 369 | WP_040089920.1 | type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA | Antitoxin |
| FFF71_RS03835 (785422) | 785422..785643 | - | 222 | WP_000692329.1 | DUF987 domain-containing protein | - |
| FFF71_RS03840 (785706) | 785706..786182 | - | 477 | WP_001347688.1 | RadC family protein | - |
| FFF71_RS03845 (786198) | 786198..786683 | - | 486 | WP_000849582.1 | antirestriction protein | - |
| FFF71_RS03850 (786738) | 786738..787556 | - | 819 | WP_001234620.1 | DUF932 domain-containing protein | - |
| FFF71_RS03855 (787656) | 787656..787889 | - | 234 | WP_001119729.1 | DUF905 family protein | - |
| FFF71_RS03860 (787968) | 787968..788423 | - | 456 | WP_000581504.1 | IrmA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14179.16 Da Isoelectric Point: 7.7761
>T37904 WP_000854748.1 NZ_AP024114:c784884-784507 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKR
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKR
Download Length: 378 bp
>T37904 NZ_AP024114:c784884-784507 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGTTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCGACTGGCCTGATGACCCGCGA
CAATTACCGAACGGTAAATAACATTACCCTGGGTAAGTATCAGGAGGCGAAACGATGA
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGTTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCGACTGGCCTGATGACCCGCGA
CAATTACCGAACGGTAAATAACATTACCCTGGGTAAGTATCAGGAGGCGAAACGATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13529.45 Da Isoelectric Point: 6.6290
>AT37904 WP_040089920.1 NZ_AP024114:c785342-784974 [Escherichia coli]
VSDTLPGTILPDDNHDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK
VSDTLPGTILPDDNHDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK
Download Length: 369 bp
>AT37904 NZ_AP024114:c785342-784974 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAATACTTCCCGACGACAATCACGACCGCCTCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACACACTCCCCGGGACAATACTTCCCGACGACAATCACGACCGCCTCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|