Detailed information of TA system TA037889

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4791424..4792222
• Replicon: chromosome
• Accession: NZ_AP024112
• Organism: Escherichia coli strain ECSC054

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: FE985_RS22895
• Protein ID: WP_000854733.1
• Coordinates: 4791845..4792222 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: FE985_RS22890
• Protein ID: WP_114213067.1
• Coordinates: 4791424..4791798 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FE985_RS22855 (4787339)	4787339..4788019	+	681	WP_001282919.1	WYL domain-containing protein	-
FE985_RS22860 (4788167)	4788167..4788844	+	678	WP_001097301.1	hypothetical protein	-
FE985_RS22865 (4788850)	4788850..4789083	+	234	WP_001278287.1	DUF905 family protein	-
FE985_RS22870 (4789173)	4789173..4789991	+	819	WP_137445153.1	DUF932 domain-containing protein	-
FE985_RS22875 (4790083)	4790083..4790568	+	486	WP_000206667.1	antirestriction protein	-
FE985_RS22880 (4790584)	4790584..4791060	+	477	WP_137445152.1	RadC family protein	-
FE985_RS22885 (4791123)	4791123..4791344	+	222	WP_000692309.1	DUF987 domain-containing protein	-
FE985_RS22890 (4791424)	4791424..4791798	+	375	WP_114213067.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
FE985_RS22895 (4791845)	4791845..4792222	+	378	WP_000854733.1	TA system toxin CbtA family protein	Toxin
FE985_RS22900 (4792219)	4792219..4792707	+	489	WP_120505567.1	DUF5983 family protein	-
FE985_RS22905 (4792719)	4792719..4792916	+	198	WP_000839243.1	DUF957 domain-containing protein	-
FE985_RS22910 (4793005)	4793005..4793851	+	847	Protein_4505	DUF4942 domain-containing protein	-
FE985_RS22915 (4793922)	4793922..4795457	+	1536	WP_120505566.1	cyclic diguanylate phosphodiesterase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4747420..4805611	58191

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14236.21 Da
• Isoelectric Point: 6.8528

>T37889 WP_000854733.1 NZ_AP024112:4791845-4792222 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNDITLGKHPEAKQ

Nucleotide

• Length: 378 bp

>T37889 NZ_AP024112:4791845-4792222 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGTTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAACTACAGAACGGTAAATGACATTACCCTGGGTAAGCATCCGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 13733.51 Da
• Isoelectric Point: 6.9458

>AT37889 WP_114213067.1 NZ_AP024112:4791424-4791798 [Escherichia coli]
VSDTPPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLANRAGIRGRFRDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADSLGSCGYVYMAVYPTLAPATTS

Nucleotide

• Length: 375 bp

>AT37889 NZ_AP024112:4791424-4791798 [Escherichia coli]
GTGTCAGACACACCCCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCAACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACTCCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACTTCATAA