Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2083723..2084557 Replicon chromosome
Accession NZ_AP024112
Organism Escherichia coli strain ECSC054

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2T3TJB4
Locus tag FE985_RS09940 Protein ID WP_000854811.1
Coordinates 2083723..2084100 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2T3TJJ3
Locus tag FE985_RS09945 Protein ID WP_001285590.1
Coordinates 2084189..2084557 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FE985_RS09900 (2079109) 2079109..2080275 + 1167 WP_000830157.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
FE985_RS09905 (2080394) 2080394..2080867 + 474 WP_001105395.1 DNA gyrase inhibitor SbmC -
FE985_RS09910 (2081066) 2081066..2082124 + 1059 WP_001200890.1 FUSC family protein -
FE985_RS09915 (2082296) 2082296..2082625 + 330 WP_000450409.1 DUF496 family protein -
FE985_RS09920 (2082726) 2082726..2082860 - 135 WP_001417572.1 EutP/PduV family microcompartment system protein -
FE985_RS09925 (2082962) 2082962..2083108 + 147 Protein_1956 transposase domain-containing protein -
FE985_RS09930 (2083397) 2083397..2083477 - 81 Protein_1957 hypothetical protein -
FE985_RS09935 (2083523) 2083523..2083726 - 204 WP_000777677.1 DUF5983 family protein -
FE985_RS09940 (2083723) 2083723..2084100 - 378 WP_000854811.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
FE985_RS09945 (2084189) 2084189..2084557 - 369 WP_001285590.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
FE985_RS09950 (2084631) 2084631..2084852 - 222 WP_000692300.1 DUF987 domain-containing protein -
FE985_RS09955 (2084921) 2084921..2085397 - 477 WP_001186771.1 RadC family protein -
FE985_RS09960 (2085413) 2085413..2085892 - 480 WP_000860074.1 antirestriction protein -
FE985_RS09965 (2085974) 2085974..2086795 - 822 WP_086167207.1 DUF932 domain-containing protein -
FE985_RS09970 (2087016) 2087016..2087426 - 411 WP_000846713.1 hypothetical protein -
FE985_RS09975 (2087442) 2087442..2088125 - 684 WP_000775499.1 hypothetical protein -
FE985_RS09980 (2088261) 2088261..2089331 - 1071 WP_137445193.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14041.14 Da        Isoelectric Point: 7.8839

>T37871 WP_000854811.1 NZ_AP024112:c2084100-2083723 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNIILGKHPEVKQ

Download         Length: 378 bp

>T37871 NZ_AP024112:c2084100-2083723 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTTCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAATATTATCCTGGGTAAGCACCCGGAGGTGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13608.50 Da        Isoelectric Point: 6.6242

>AT37871 WP_001285590.1 NZ_AP024112:c2084557-2084189 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLYSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT37871 NZ_AP024112:c2084557-2084189 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
ACAGCAATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T3TJB4

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3TJJ3

References