Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1041762..1042416 Replicon chromosome
Accession NZ_AP024112
Organism Escherichia coli strain ECSC054

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag FE985_RS05005 Protein ID WP_000244781.1
Coordinates 1042009..1042416 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0V9GG32
Locus tag FE985_RS05000 Protein ID WP_001564007.1
Coordinates 1041762..1042028 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FE985_RS04980 (1037850) 1037850..1039283 - 1434 WP_001564009.1 6-phospho-beta-glucosidase BglA -
FE985_RS04985 (1039328) 1039328..1039639 + 312 WP_001182966.1 N(4)-acetylcytidine aminohydrolase -
FE985_RS04990 (1039803) 1039803..1040462 + 660 WP_000250274.1 hemolysin III family protein -
FE985_RS04995 (1040539) 1040539..1041519 - 981 WP_001564008.1 tRNA-modifying protein YgfZ -
FE985_RS05000 (1041762) 1041762..1042028 + 267 WP_001564007.1 FAD assembly factor SdhE Antitoxin
FE985_RS05005 (1042009) 1042009..1042416 + 408 WP_000244781.1 protein YgfX Toxin
FE985_RS05010 (1042456) 1042456..1042977 - 522 WP_001055874.1 flavodoxin FldB -
FE985_RS05015 (1043089) 1043089..1043985 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
FE985_RS05020 (1044010) 1044010..1044720 + 711 WP_001564005.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FE985_RS05025 (1044726) 1044726..1046459 + 1734 WP_001564004.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T37867 WP_000244781.1 NZ_AP024112:1042009-1042416 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T37867 NZ_AP024112:1042009-1042416 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10565.15 Da        Isoelectric Point: 5.1599

>AT37867 WP_001564007.1 NZ_AP024112:1041762-1042028 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWMMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT37867 NZ_AP024112:1041762-1042028 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGATGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9GG32

References