Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3346368..3346983 Replicon chromosome
Accession NZ_AP024109
Organism Mesorhizobium sp. J8

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag MJ8_RS15975 Protein ID WP_201415456.1
Coordinates 3346798..3346983 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID -
Locus tag MJ8_RS15970 Protein ID WP_201409857.1
Coordinates 3346368..3346766 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJ8_RS15945 3341989..3343032 + 1044 WP_201415245.1 glycerophosphodiester phosphodiesterase family protein -
MJ8_RS15950 3343237..3344109 - 873 WP_201415246.1 aldo/keto reductase family oxidoreductase -
MJ8_RS15955 3344205..3345113 + 909 WP_201415247.1 LysR family transcriptional regulator -
MJ8_RS15960 3345168..3345638 - 471 WP_040999876.1 30S ribosomal protein S9 -
MJ8_RS15965 3345638..3346102 - 465 WP_040983169.1 50S ribosomal protein L13 -
MJ8_RS15970 3346368..3346766 - 399 WP_201409857.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MJ8_RS15975 3346798..3346983 - 186 WP_201415456.1 type II toxin-antitoxin system HicA family toxin Toxin
MJ8_RS15980 3347028..3347483 - 456 WP_201409858.1 PaaI family thioesterase -
MJ8_RS15985 3347638..3348459 + 822 WP_201409859.1 enoyl-CoA hydratase -
MJ8_RS15990 3348504..3349286 + 783 WP_201409860.1 AAA family ATPase -
MJ8_RS15995 3349279..3350052 + 774 WP_201409861.1 GNAT family N-acetyltransferase -
MJ8_RS16000 3350049..3350570 + 522 WP_201409862.1 CoA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6953.13 Da        Isoelectric Point: 11.7888

>T37861 WP_201415456.1 NZ_AP024109:c3346983-3346798 [Mesorhizobium sp. J8]
IERDSRRIIKRLREDGFELVSVRGSHHKFRKGAVVLVVPHPEKDLPVGTARAIAKQAGWIR

Download         Length: 186 bp

>T37861 NZ_AP024109:c3346983-3346798 [Mesorhizobium sp. J8]
ATCGAGCGCGACAGCCGCCGCATCATAAAGCGGTTGAGGGAGGACGGCTTCGAATTGGTTTCAGTTCGGGGTTCGCATCA
CAAATTCCGAAAAGGGGCCGTCGTGCTTGTTGTTCCGCACCCGGAAAAAGACCTGCCAGTCGGCACCGCTCGCGCGATTG
CCAAGCAAGCAGGCTGGATCCGCTAG

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14223.02 Da        Isoelectric Point: 4.4194

>AT37861 WP_201409857.1 NZ_AP024109:c3346766-3346368 [Mesorhizobium sp. J8]
MKNYFALVEKDADSAFGIRFPDIPGCFSAADVPEDIVPNAVEALQLWAEDISVPEPSSHEAIVSLPDVRAALSEGAYLVS
VPLIDNDSAVVRANVTFERGVLRAIDAAARERGITRSAFLSSAARREIEAKH

Download         Length: 399 bp

>AT37861 NZ_AP024109:c3346766-3346368 [Mesorhizobium sp. J8]
ATGAAGAACTACTTCGCGCTGGTTGAGAAGGATGCCGACAGCGCGTTTGGTATTCGGTTCCCCGACATTCCGGGCTGCTT
TTCGGCTGCCGACGTACCCGAGGATATCGTGCCGAATGCAGTCGAGGCCCTCCAACTTTGGGCCGAGGATATCTCCGTGC
CTGAGCCATCCAGCCACGAGGCGATTGTATCGCTTCCCGATGTCCGTGCCGCACTGTCGGAAGGAGCATATTTAGTTTCC
GTGCCGCTGATCGACAATGACAGCGCTGTGGTCAGGGCTAACGTGACGTTCGAACGCGGTGTCCTACGTGCGATCGATGC
CGCCGCGCGCGAGCGCGGCATTACCAGGTCCGCATTTCTCTCAAGCGCCGCCCGCAGGGAAATCGAAGCCAAGCACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References