Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2541650..2542323 Replicon chromosome
Accession NZ_AP024109
Organism Mesorhizobium sp. J8

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MJ8_RS11755 Protein ID WP_201414520.1
Coordinates 2541901..2542323 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MJ8_RS11750 Protein ID WP_201415397.1
Coordinates 2541650..2541904 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJ8_RS11725 2537333..2538412 - 1080 WP_201415396.1 phosphoribosylformylglycinamidine cyclo-ligase -
MJ8_RS11730 2538597..2539229 + 633 WP_201414516.1 CDP-alcohol phosphatidyltransferase family protein -
MJ8_RS11735 2539243..2540388 + 1146 WP_201414517.1 AI-2E family transporter -
MJ8_RS11740 2540390..2541094 + 705 WP_201414518.1 hypothetical protein -
MJ8_RS11745 2541198..2541461 - 264 WP_201414519.1 hypothetical protein -
MJ8_RS11750 2541650..2541904 + 255 WP_201415397.1 Arc family DNA-binding protein Antitoxin
MJ8_RS11755 2541901..2542323 + 423 WP_201414520.1 type II toxin-antitoxin system VapC family toxin Toxin
MJ8_RS11760 2542486..2543208 - 723 WP_201414521.1 hypothetical protein -
MJ8_RS11770 2543424..2544599 - 1176 WP_201415398.1 NAD(P)/FAD-dependent oxidoreductase -
MJ8_RS11775 2544735..2545703 - 969 WP_201414522.1 NAD(P)H-dependent oxidoreductase -
MJ8_RS11780 2545948..2546253 + 306 WP_041001802.1 ETC complex I subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 14796.02 Da        Isoelectric Point: 5.1297

>T37860 WP_201414520.1 NZ_AP024109:2541901-2542323 [Mesorhizobium sp. J8]
MILLDTNVVSEVMRPQPNAAVLAWLDERVAETLYLSSVTVAEVLFGIEAMPASRRKNALAEAFGGICAVFDQRILAFDAE
AARHYAGLAVKARAAGKGFPVPDGYIAAIAAAKGFQVASRDTAPFYAASVSVINPWEPAA

Download         Length: 423 bp

>T37860 NZ_AP024109:2541901-2542323 [Mesorhizobium sp. J8]
ATGATCCTGTTGGACACCAATGTCGTTTCGGAGGTGATGAGACCACAACCTAACGCTGCGGTCCTGGCTTGGCTGGACGA
GCGGGTAGCCGAGACGCTCTATCTGTCCAGCGTCACCGTGGCGGAAGTGCTGTTCGGCATCGAGGCCATGCCTGCCAGCC
GGCGCAAAAATGCGCTGGCCGAAGCCTTTGGCGGGATTTGTGCAGTCTTCGATCAGCGCATCCTGGCCTTCGACGCCGAG
GCGGCGCGCCACTATGCCGGTCTCGCCGTAAAGGCGAGAGCCGCCGGAAAGGGGTTTCCCGTGCCTGATGGATACATCGC
AGCCATCGCCGCCGCGAAAGGCTTTCAGGTCGCGTCGCGCGACACGGCGCCGTTTTATGCGGCCAGTGTGTCCGTGATCA
ACCCGTGGGAGCCCGCAGCCTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9230.57 Da        Isoelectric Point: 11.3030

>AT37860 WP_201415397.1 NZ_AP024109:2541650-2541904 [Mesorhizobium sp. J8]
MAAVTVRNLPEETHRALRVRAAINGRSTEAEIRAILEAAVRPESRVRVGTLLSAIARRSGVTNKDVEALEQARQKSPAEP
LKFE

Download         Length: 255 bp

>AT37860 NZ_AP024109:2541650-2541904 [Mesorhizobium sp. J8]
ATGGCTGCTGTTACGGTCAGAAACCTTCCGGAGGAAACGCATCGTGCCTTACGGGTGCGCGCGGCCATCAATGGCCGCAG
CACGGAGGCGGAAATCCGCGCCATTCTTGAAGCCGCGGTTCGGCCGGAAAGCCGCGTCAGGGTAGGCACCCTATTGTCTG
CCATCGCTCGCCGATCGGGCGTGACGAACAAGGACGTCGAAGCACTTGAACAAGCCCGTCAAAAAAGCCCGGCTGAGCCG
CTGAAGTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References